Rabbit anti-Mouse Fragile X Mental Retardation, Autosomal Homolog 1, L662 Polyclonal Antibody

Fragile X Mental Retardation, Autosomal Homolog 1, L662 (FXR1, Fragile X Mental Retardation Syndrome-related Protein 1, Fragile X Mental Retardation-related Protein 1, hFXR1p)

Cat. Num. AAA620693

• Reactivity: Mouse
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: Fragile X Mental Retardation; Autosomal Homolog 1; L662; Polyclonal Antibody; L662 (FXR1; Fragile X Mental Retardation Syndrome-related Protein 1; Fragile X Mental Retardation-related Protein 1; hFXR1p); Anti -Fragile X Mental Retardation; anti-Fragile X Mental Retardation; L662 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recongnizes endogenous levels of mouse total FXR1 protein.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in 10mM sodium HEPES pH 7.5, 150mM sodium chloride,0.1mg/ml BSA and 50% glycerol.

• Applicable Applications for anti-Fragile X Mental Retardation, Autosomal Homolog 1, L662 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot: 1:1000; Incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4 degree C with gentle shaking, overnight.
• Immunogen: Synthetic peptide derived from the sequence of mouse FXR1 protein (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of extracts from C2C12 cells using MBS620693.)

Western Blot (WB)

(Western Blot analysis of extracts from mouse skeletal muscle using MBS620693.)

Related Product Information for anti-Fragile X Mental Retardation, Autosomal Homolog 1, L662 antibody

Fragile X syndrome is a genetic disorder characterized by a spectrum of physical and behavioral features and is a frequent form of inherited mental retardation (1). The X-linked FMRP (FMR-1) and its two autosomal homologs, FXR1 and FXR2, are polyribosome-associated RNA-binding proteins that are involved in the pathogenesis of fragile X syndrome (1-3). Each of the fragile X proteins can self-associate as well as form heteromers with the other two related proteins (3). FMRP can act as a translation regulator and is a component of RNAi effector complexes (RISC), suggesting a role in gene silencing (4). The Drosophila homolog of FMRP (dFMRP) associates with Argonaute2 (Ago2) and Dicer and can coimmunoprecipitate with miRNA and siRNA (5). These results suggest that fragile X syndrome is related to abnormal translation caused by defects in RNAi-related pathways.

Product Categories/Family for anti-Fragile X Mental Retardation, Autosomal Homolog 1, L662 antibody

Antibodies; Abs to Disease Markers