Rabbit FXR2 Polyclonal Antibody | anti-FXR2 antibody

FXR2 (FMR1L2, Fragile X Mental Retardation Syndrome-related Protein 2) APC

Cat. Num. AAA6379055

• Gene Names: FXR2; FXR2P; FMR1L2
• Reactivity: Human, Mouse, Rabbit
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: FXR2; Polyclonal Antibody; FXR2 (FMR1L2; Fragile X Mental Retardation Syndrome-related Protein 2) APC; anti-FXR2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human FXR2. Species Crossreactivity: mouse.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-FXR2 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human FXR2, aa1-673 (AAH51907.1).
• Immunogen Sequence: MGGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPPPADYNKEITEGDEVEVYSRANEQEPCGWWLARVRMMKGDFYVIEYAACDATYNEIVTLERLRPVNPNPLATKGSFFKVTMAVPEDLREACSNENVHKEFKKALGANCIFLNITNSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLMSRNEEATKHLETSKQLAAAFQEEFTVREDLMGLAIGTHGANIHQARKVPGVTAIELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRVEGDNDKKNPREEGMVPFIFVGTRENISNAQALLEYHLSYLQEVEQLRLERLQIDEQLRQIGLGFRPPGSGRGSGGSDKAGYSTDESSSSSLHATRTYGGSYGGRGRGRRTGGPAYGPSSDVSTASETESEKREEPNRAGPGDRDPPTRGEESRRRPTGGRGRGPPPAPRPTSRYNSSSISSVLKDPDSNPYSLLDTSEPEPPVDSEPGEPPPASARRRRSRRRRTDEDRTVMDGGLESDGPNMTENGLEDESRPQRRNRSRRRRNRGNRTDGSISGDRQPVTVADYISRAESQSRQRPPLERTKPSEDSLSGQKGDSVSKLPKGPSENGELSAPLELGSMVNGVSj
• Conjugate: APC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(FXR2 rabbit polyclonal antibody. Western Blot analysis of FXR2 expression in mouse kidney.)

Western Blot (WB)

(Western Blot analysis of FXR2 expression in transfected 293T cell line by FXR2 polyclonal antibody. Lane 1: FXR2 transfected lysate (74.2kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-FXR2 antibody

Fragile X syndrome is caused by the absence of the fragile X mental-retardation protein (FMRP). FMRP is the archetype of a class of cytoplasmic mRNA-binding proteins that includes the fragile X-related 1 and 2 proteins (FXR1 and FXR2). The fragile X-related proteins FXR1 and FXR2 contain a functional nucleolar-targeting signal equivalent to the HIV-1 regulatory proteins.

Product Categories/Family for anti-FXR2 antibody

Antibodies; Disease Markers

NCBI and Uniprot Product Information

• NCBI GI #: 30354025
• NCBI GeneID: 9513
• UniProt Accession #: P51116; Q86V09; Q8WUM2; B2R9M2; D3DTQ1
• Molecular Weight: 74,223 Da
• NCBI Official Full Name: Homo sapiens fragile X mental retardation, autosomal homolog 2, mRNA
• NCBI Official Synonym Full Names: fragile X mental retardation, autosomal homolog 2
• NCBI Official Symbol: FXR2
• NCBI Official Synonym Symbols: FXR2P; FMR1L2
• NCBI Protein Information: fragile X mental retardation syndrome-related protein 2; fragile X-mental retardation 1-like 2
• UniProt Protein Name: Fragile X mental retardation syndrome-related protein 2
• Protein Family: Fragile X mental retardation syndrome-related protein
• UniProt Gene Name: FXR2
• UniProt Synonym Gene Names: FMR1L2
• UniProt Entry Name: FXR2_HUMAN

NCBI Description

The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome. [provided by RefSeq, Jul 2008]

Uniprot Description

FXR2: RNA-binding protein. Interacts with FMR1 and FXR1. Interacts with CYFIP2 but not with CYFIP1. Interacts with TDRD3. Belongs to the FMR1 family.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: polysome; membrane; cytoplasm; nucleus

Molecular Function: mRNA binding; identical protein binding; protein binding; RNA binding

Biological Process: negative regulation of translation