Rabbit anti-Human FOXP1, Isoform 1 Polyclonal Antibody | anti-FOXP1 antibody

FOXP1, Isoform 1 (Forkhead Box P1)

Cat. Num. AAA615273

• Gene Names: FOXP1; QRF1; 12CC4; hFKH1B; HSPC215; FLJ23741; MGC12942; MGC88572; MGC99551
• Reactivity: Human
• Applications: ELISA
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: FOXP1; Isoform 1; Polyclonal Antibody; Isoform 1 (Forkhead Box P1); Anti -FOXP1; anti-FOXP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human FOXP1.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, sodium azide, before the addition of glycerol to 40%.

• Applicable Applications for anti-FOXP1 antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.; Dilution: ELISA Titer: 1:250,000.
• Immunogen: Synthetic peptide, QVSGLKSPKRNDKQP of human FOXP1 (KLH). Molecular Weight: 75.31kD.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-FOXP1 antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 18644886
• NCBI GeneID: 27086
• NCBI Accession #: NP_116071.2
• NCBI GenBank Nucleotide #: NM_032682.4
• UniProt Accession #: Q548T7; Q6IAJ1; Q8IXF4; Q8N2P0; Q8NAN6; Q8TEA2; Q9BSG9; Q9H334
• Molecular Weight: 75,317 Da
• NCBI Official Full Name: forkhead box protein P1 isoform 1
• NCBI Official Synonym Full Names: forkhead box P1
• NCBI Official Symbol: FOXP1
• NCBI Official Synonym Symbols: QRF1; 12CC4; hFKH1B; HSPC215; FLJ23741; MGC12942; MGC88572; MGC99551
• NCBI Protein Information: forkhead box protein P1; OTTHUMP00000213499; OTTHUMP00000213500; OTTHUMP00000213501; OTTHUMP00000213502; OTTHUMP00000213503; OTTHUMP00000213504; OTTHUMP00000213506; OTTHUMP00000213507; OTTHUMP00000213508; glutamine-rich factor 1; fork head-related protein like B
• UniProt Protein Name: 12CC4
• Protein Family: Forkhead box protein
• UniProt Gene Name: FOXP1
• UniProt Entry Name: Q548T7_HUMAN

NCBI Description

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

Uniprot Description

FOXP1: Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development. Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Cell cycle regulation; Transcription factor; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 3p14.1

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; androgen receptor binding; sequence-specific DNA binding; metal ion binding

Biological Process: transcription from RNA polymerase II promoter; positive regulation of smooth muscle cell proliferation; response to lipopolysaccharide; osteoclast differentiation; endothelial cell activation; regulation of transcription from RNA polymerase II promoter; regulation of monocyte differentiation; macrophage activation; monocyte activation; regulation of inflammatory response; regulation of interleukin-1 beta secretion; regulation of tumor necrosis factor production; negative regulation of transcription, DNA-dependent; negative regulation of B cell apoptosis

Disease: Mental Retardation With Language Impairment And With Or Without Autistic Features