Rabbit anti-Human FOXL2 Polyclonal Antibody | anti-FOXL2 antibody

FOXL2 Antibody

Cat. Num. AAA7107879

• Gene Names: FOXL2; BPES; PFRK; POF3; BPES1; PINTO
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: >95%, Protein G purified
• Synonyms: FOXL2; Polyclonal Antibody; FOXL2 Antibody; Forkhead box protein L2; anti-FOXL2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 376

• Applicable Applications for anti-FOXL2 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WB: 1:500-1:5000
• Immunogen: Recombinant Human Forkhead box protein L2 protein (116-216AA)
• Conjugation: Non-conjugated
• Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western BlotPositive WB detected in: A549 whole cell lysateAll lanes: FOXL2 antibody at 3.7ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 39 KDaObserved band size: 49 KDa)

Related Product Information for anti-FOXL2 antibody

Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.

Product Categories/Family for anti-FOXL2 antibody

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 12751477
• NCBI GeneID: 668
• NCBI Accession #: NP_075555.1
• NCBI GenBank Nucleotide #: NM_023067.3
• UniProt Accession #: P58012; Q4ZGJ3
• Molecular Weight: 38,772 Da
• NCBI Official Full Name: forkhead box protein L2
• NCBI Official Synonym Full Names: forkhead box L2
• NCBI Official Symbol: FOXL2
• NCBI Official Synonym Symbols: BPES; PFRK; POF3; BPES1; PINTO
• NCBI Protein Information: forkhead box protein L2
• UniProt Protein Name: Forkhead box protein L2
• Protein Family: Forkhead box protein
• UniProt Gene Name: FOXL2

NCBI Description

This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Expansion of a polyalanine repeat region and other mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. [provided by RefSeq, Jul 2016]

Uniprot Description

Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (). Is a regulator of CYP19 expression (). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.