Rabbit FoxL1 Polyclonal Antibody | anti-FoxL1 antibody

FoxL1 (G150) Polyclonal Antibody

Cat. Num. AAA3002439

• Gene Names: FOXL1; FKH6; FKHL11; FREAC7
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: FoxL1; Polyclonal Antibody; FoxL1 (G150) Polyclonal Antibody; Forkhead box protein L1; Forkhead-related protein FKHL11; Forkhead-related transcription factor 7; FREAC-7; FKHL11; FREAC7; FOXL1; anti-FoxL1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: FoxL1 (G150) polyclonal antibody detects endogenous levels of FoxL1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 345

• Applicable Applications for anti-FoxL1 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Testing Data

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of FoxL1 (G150) pAb in paraffin-embedded human lung carcinoma tissue at 1:50.showing Cytoplasm and Nuclear staining. Negative control (the right) Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.)

Related Product Information for anti-FoxL1 antibody

FOXL1 is a 337 amino acid protein encoded by the mouse gene Foxl1. FOXL1 belongs to the fork head family and contains one fork head DNA-binding domain. The HNF3/fork head family includes a large number of transcription factors that share a structurally related DNA binding domain. Fork head factors are known to play important roles both during development and in adults. FOXL1 is a winged helix transcriptional regulator expressed in the mesenchymal layer of developing and mature gastrointestinal tract. FOXL1- deficient mice exhibit various defects not only in the epithelial layer of the gastrointestinal tract but also in gut-associated lymphoid tissues. In the small intestine of FOXL1-deficient mice, the formation of Peyers patches is affected, particularly in the caudal region. FOXL1 is a mesenchymal modifier of the adenomatous polyposis coli (APC) gene products and plays a key role in gastrointestinal tumorigenesis.

NCBI and Uniprot Product Information

• NCBI GI #: 22779860
• NCBI GeneID: 2300
• NCBI Accession #: NP_005241.1
• NCBI GenBank Nucleotide #: NP_005241.1
• UniProt Accession #: Q12952
• Molecular Weight: ~ 36kDa
• NCBI Official Full Name: forkhead box protein L1
• NCBI Official Synonym Full Names: forkhead box L1
• NCBI Official Symbol: FOXL1
• NCBI Official Synonym Symbols: FKH6; FKHL11; FREAC7
• NCBI Protein Information: forkhead box protein L1
• UniProt Protein Name: Forkhead box protein L1
• Protein Family: Forkhead box protein
• UniProt Gene Name: FOXL1
• UniProt Synonym Gene Names: FKHL11; FREAC7; FREAC-7
• UniProt Entry Name: FOXL1_HUMAN

NCBI Description

This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors are characterized by a distinct DNA-binding forkhead domain and play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. [provided by RefSeq, Nov 2012]

Uniprot Description

FOXL1: Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 16q24

Cellular Component: nucleus

Molecular Function: DNA binding; sequence-specific DNA binding; DNA bending activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; organ morphogenesis; multicellular organismal development; heart development; proteoglycan biosynthetic process; regulation of Wnt receptor signaling pathway; visceral mesoderm-endoderm interaction involved in midgut development