Immunohistochemistry (IHC)
((2ug/ml) staining of paraffin embedded Human Thyroid Gland. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.)
Goat FOXE1/TTF2 Polyclonal Antibody | anti-FOXE1 antibody
Goat anti-FOXE1/TTF2 Antibody
Immunohistochemistry: In paraffin embedded Human Thyroid Gland shows nuclear staining in thyrocytes. Recommended concentration, 2-4ug/ml.
Western Blot: Preliminary experiments gave an approx 70kDa band in Human Thymus and Thyroid Gland lysates after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 38.1kDa according to NP_004464.2. The 70kDa band was successfully blocked by incubation with the immunizing peptide.
Immunohistochemistry (IHC)
((2ug/ml) staining of paraffin embedded Human Thyroid Gland. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.)
Immunohistochemistry (IHC)
((2ug/ml) staining of paraffin embedded Human Thyroid Gland. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.)
NCBI and Uniprot Product Information
NCBI Description
This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I. [provided by RefSeq, Jul 2008]
Uniprot Description
FOXE1: Probable transcription factor. Could be involved in thyroid gland organogenesis. Defects in FOXE1 are the cause of Bamforth-Lazarus syndrome (BLS). BLS is associated with thyroid agenesis, cleft palate and choanal atresia.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 9q22
Cellular Component: nucleus
Molecular Function: DNA binding; sequence-specific DNA binding; transcription factor activity
Biological Process: anatomical structure morphogenesis; cell migration; embryonic organ morphogenesis; hair follicle morphogenesis; hard palate development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; soft palate development; thymus development; thyroid gland development; thyroid hormone generation; transcription, DNA-dependent
Disease: Hypothyroidism, Athyroidal, With Spiky Hair And Cleft Palate; Thyroid Cancer, Nonmedullary, 4
Research Articles on FOXE1
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Product Notes
The FOXE1 foxe1 (Catalog #AAA420836) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-FOXE1/TTF2 Antibody reacts with Tested: Human; Expected from sequence similarity: Human and may cross-react with other species as described in the data sheet. AAA Biotech's FOXE1/TTF2 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Immunohistochemistry (IHC). Peptide ELISA: Antibody detection limit dilution 1: 8000. Immunohistochemistry: In paraffin embedded Human Thyroid Gland shows nuclear staining in thyrocytes. Recommended concentration, 2-4ug/ml. Western Blot: Preliminary experiments gave an approx 70kDa band in Human Thymus and Thyroid Gland lysates after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 38.1kDa according to NP_004464.2. The 70kDa band was successfully blocked by incubation with the immunizing peptide. Researchers should empirically determine the suitability of the FOXE1 foxe1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: AYPGGIDRFV SAM. It is sometimes possible for the material contained within the vial of "FOXE1/TTF2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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