Immunohistochemistry (IHC)
(FOXE1 (dilution: 2.5ug/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Protocol on Data-sheet.)
Goat anti-Human FOXE1 Antibody | anti-FOXE1 antibody
FOXE1
Immunohistochemistry (IHC)
(FOXE1 (dilution: 2.5ug/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Protocol on Data-sheet.)
Immunohistochemistry (IHC)
(FOXE1 (dilution: 2.5ug/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Protocol on Data-sheet.)
Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I.
NCBI and Uniprot Product Information
NCBI Description
This intronless gene encodes a protein that belongs to the forkhead family of transcription factors. Members of this family contain a conserved 100-amino acid DNA-binding 'forkhead' domain. The encoded protein functions as a thyroid transcription factor that plays a role in thyroid morphogenesis. Mutations in this gene are associated with the Bamforth-Lazarus syndrome, and with susceptibility to nonmedullary thyroid cancer-4. [provided by RefSeq, Nov 2016]
Uniprot Description
FOXE1: Probable transcription factor. Could be involved in thyroid gland organogenesis. Defects in FOXE1 are the cause of Bamforth-Lazarus syndrome (BLS). BLS is associated with thyroid agenesis, cleft palate and choanal atresia.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 9q22
Cellular Component: nucleus
Molecular Function: DNA binding; sequence-specific DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; anatomical structure morphogenesis; cell migration; hair follicle morphogenesis; thymus development; positive regulation of transcription, DNA-dependent; thyroid hormone generation; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; embryonic organ morphogenesis; thyroid gland development; hard palate development; soft palate development; negative regulation of transcription, DNA-dependent
Disease: Hypothyroidism, Athyroidal, With Spiky Hair And Cleft Palate; Thyroid Cancer, Nonmedullary, 4
Research Articles on FOXE1
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Product Notes
The FOXE1 foxe1 (Catalog #AAA555920) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The FOXE1 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FOXE1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), ELISA (EIA). Researchers should empirically determine the suitability of the FOXE1 foxe1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FOXE1, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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