Rabbit anti-Human Fos Polyclonal Antibody | anti-FOS antibody

Fos, phosphorylated (Thr232) (c-Fos)

Cat. Num. AAA630529

• Gene Names: FOS; AP-1; C-FOS
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Fos; Polyclonal Antibody; phosphorylated (Thr232) (c-Fos); Anti -Fos; anti-FOS antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human c-Fos when phosphorylated at Thr232. Species homology: mouse and rat c-Fos (100%).
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS (without Mg2+ and Ca2+) pH 7.3, 1mg/ml BSA (IgG, protease free), 0.05% sodium azide, 50% glycerol.

• Applicable Applications for anti-FOS antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot: 1:1000; Optimal dilution determined by the researcher.
• Immunogen: Synthetic phosphopeptide derived from the region of human c-Fos that contains threonine 232. The sequence is conserved in mouse and rat.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-FOS antibody

c-Fos is a ~60kD immediate early gene product and a member of AP-1 family. c-Fos dimerizes with c-Jun to form the transcriptionally active complex AP-1, and functions in regulating cell proliferation and differentiation. c-Fos expression and activation are induced in many tumors including breast cancer), and in response to a variety of stimuli (including growth factors, cytokines and stress). ERK1&2 mediate growth factor-induced c-Fos induction and transcripional activation by directly phosphorylating the carboxyl terminal domain of c-Fos. c-Fos is phosphorylated by Ras on threonine 232, the homologue of serine 73 of c-Jun, which results in augmenting its transcriptional activity.

Product Categories/Family for anti-FOS antibody

Antibodies; Abs to Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 49457528
• NCBI GeneID: 2353
• UniProt Accession #: Q6FG41; P01100; Q76MY9; Q76MZ0
• Molecular Weight: 40,695 Da
• NCBI Official Full Name: FOS
• NCBI Official Synonym Full Names: FBJ murine osteosarcoma viral oncogene homolog
• NCBI Official Symbol: FOS
• NCBI Official Synonym Symbols: AP-1; C-FOS
• NCBI Protein Information: proto-oncogene c-Fos; activator protein 1; cellular oncogene fos; cellular oncogene c-fos; G0/G1 switch regulatory protein 7; v-fos FBJ murine osteosarcoma viral oncogene homolog; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)
• UniProt Protein Name: FOS protein
• Protein Family: Fos-related antigen
• UniProt Gene Name: FOS
• UniProt Entry Name: Q6FG41_HUMAN

NCBI Description

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq]

Uniprot Description

Sequence similarities: Belongs to the bZIP family. RuleBase RU000470Contains 1 bZIP domain. SAAS SAAS011616