Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human lung cancer tissue using FNIP2 Polyclonal Antibody at dilution of 1:30(×200))
Rabbit anti-Human FNIP2 Polyclonal Antibody | anti-FNIP2 antibody
FNIP2 Polyclonal Antibody
ELISA: 1:5000-1:10000
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human lung cancer tissue using FNIP2 Polyclonal Antibody at dilution of 1:30(×200))
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human lung cancer tissue using FNIP2 Polyclonal Antibody at dilution of 1:30(×200))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]
Uniprot Description
FNIP2: May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. Belongs to the FNIP family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 4q32.1
Cellular Component: nucleoplasm; cytoplasm; plasma membrane; microtubule organizing center
Molecular Function: protein binding
Biological Process: regulation of protein amino acid phosphorylation; DNA damage response, signal transduction resulting in induction of apoptosis; negative regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; positive regulation of peptidyl-serine phosphorylation
Research Articles on FNIP2
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Product Notes
The FNIP2 fnip2 (Catalog #AAA2559862) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FNIP2 Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FNIP2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), ELISA (EIA). IHC: 1:25-1:100 ELISA: 1:5000-1:10000. Researchers should empirically determine the suitability of the FNIP2 fnip2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FNIP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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