Immunohistochemistry (IHC)
(Immunochemical staining of human FLVCR1 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human FLVCR1 Polyclonal Antibody | anti-FLVCR1 antibody
Anti-FLVCR1 Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
FLVCR1; Polyclonal Antibody; Anti-FLVCR1 Antibody; Rabbit Polyclonal; FLVCR1 Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-AXPC1 Antibody; Anti-FLVCR Antibody; Anti-MFSD7B Antibody; Anti-PCA Antibody; Anti-PCARP Antibody; anti-FLVCR1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human FLVCR1
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-FLVCR1 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:50-1:200
Immunogen
E Coli-derived Human FLVCR1 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human FLVCR1 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human FLVCR1 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human FLVCR1 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-FLVCR1 antibody
Feline leukemia virus subgroup C receptor 1 (FLVCR1), a member of the SLC49 family of four paralogous genes, is a transmembrane protein. FLVCR1 is a cell surface heme exporter, essential for erythropoiesis and systemic iron homeostasis. Disruption of FLVCR1 function blocks development of erythroid progenitors, likely due to heme toxicity. FLVCR1 has a crucial role in a variety of biological processes, including cell proliferation, cell death, apoptosis, oxidative stress response, cellular differentiation and metabolism. FLVCR1 gene mutation is in association with a clinical syndrome of posterior column ataxia with retinitis pigmentosa (PCARP). FLVCR1 may act as an oncoprotein, and have key roles in promoting proliferation and tumorigenicity of synovial sarcoma (SS), and this may shed new light on finding novel therapeutic strategies against SS.
References
Yusuf IH, et al. (2018) A splice-site variant in flvcr1 produces retinitis pigmentosa without posterior column ataxia. Ophthalmic Genet 39 (2): 263-267.Peng C, et al. (2018) Flvcr1 promotes the proliferation and tumorigenicity of synovial sarcoma through inhibiting apoptosis and autophagy. Int J Oncol 52 (5): 1559-1568.Khan AA, et al. (2013) Heme and flvcr-related transporter families slc48 and slc49. Mol Aspects Med 34 (2-3): 669-682.
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Product Notes
The FLVCR1 (Catalog #AAA8109624) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-FLVCR1 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FLVCR1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:50-1:200. Researchers should empirically determine the suitability of the FLVCR1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FLVCR1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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