Rabbit anti-Human, Mouse FLRT3 Polyclonal Antibody | anti-FLRT3 antibody

FLRT3 Antibody

Cat. Num. AAA7044838

• Gene Names: FLRT3; HH21
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunofluorescence
• Purity: >95%, Protein G purified
• Synonyms: FLRT3; Polyclonal Antibody; FLRT3 Antibody; Leucine-rich repeat transmembrane protein FLRT3; Fibronectin-like domain-containing leucine-rich transmembrane protein 3; KIAA1469; UNQ856/PRO1865; anti-FLRT3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 649

• Applicable Applications for anti-FLRT3 antibody: ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
• Species: Human
• Immunogen: Recombinant human Leucine-rich repeat transmembrane protein FLRT3 protein
• Conjugate: Non-conjugated
• Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-82155 / sc-82156 / sc-98656
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western blotAll lanes: DARS2 antibody at 16ug/mlLane 1: Mouse heart tissueLane 2: Mouse liver tissueLane 3: Mouse brain tissueLane 4: Mouse skeletal muscle tissueSecondaryGoat polyclonal to rabbit IgG at 1/10000 dilutionPredicted band size: 73 kDaObserved band size: 73 kDa)

Immunofluorescence (IF)

(Immunofluorescent analysis of HepG-2 cells using MBS7044838 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))

Related Product Information for anti-FLRT3 antibody

Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:26235030). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (By similarity). Promotes neurite outgrowth (in vitro) (PubMed:14706654). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 7019383
• NCBI GeneID: 23767
• NCBI Accession #: NP_037413.1
• NCBI GenBank Nucleotide #: NM_013281.3
• UniProt Accession #: Q9NZU0; Q542Z9; Q96K39; Q96K42; Q96KB1; Q9P259; D3DW20
• Molecular Weight: 73,004 Da
• NCBI Official Full Name: leucine-rich repeat transmembrane protein FLRT3
• NCBI Official Synonym Full Names: fibronectin leucine rich transmembrane protein 3
• NCBI Official Symbol: FLRT3
• NCBI Official Synonym Symbols: HH21
• NCBI Protein Information: leucine-rich repeat transmembrane protein FLRT3
• UniProt Protein Name: Leucine-rich repeat transmembrane protein FLRT3
• Protein Family: Leucine-rich repeat transmembrane protein
• UniProt Gene Name: FLRT3
• UniProt Synonym Gene Names: KIAA1469
• UniProt Entry Name: FLRT3_HUMAN

NCBI Description

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRTs may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. This gene is expressed in many tissues. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2010]

Uniprot Description

FLRT3: May have a function in cell adhesion and/or receptor signaling.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: 20p11

Cellular Component: cytoplasm; integral to plasma membrane; nerve terminal; plasma membrane

Molecular Function: protein binding; protein homodimerization activity; protein kinase inhibitor activity

Biological Process: cytokine and chemokine mediated signaling pathway; embryonic morphogenesis; fibroblast growth factor receptor signaling pathway; heart development; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity; neurite development; response to axon injury; synaptogenesis

Disease: Hypogonadotropic Hypogonadism 21 With Or Without Anosmia