Rabbit FKBP15 Polyclonal Antibody | anti-FKBP15 antibody

FKBP15 Antibody

Cat. Num. AAA150935

• Gene Names: FKBP15; FKBP133; PPP1R76; KIAA0674
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: FKBP15 Antibody is affinity chromatography purified via peptide column.
• Synonyms: FKBP15; Polyclonal Antibody; FKBP15 Antibody; FKBP133; PPP1R76; KIAA0674; FK506-binding protein 15; 133 kDa FK506-binding protein; FKBP-15; FK506 binding protein 15; 133kDa; anti-FKBP15 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: FKBP15 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 1219

• Applicable Applications for anti-FKBP15 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: FKBP15 antibody can be used for detection of FKBP15 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: FKBP15 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human FKBP15.
• Buffer: FKBP15 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: FKBP15 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of FKBP15 in 3T3 cell lysate with FKBP15 antibody at 1 μg/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of FKBP15 in mouse brain tissue with FKBP15 antibody at 2.5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of FKBP15 in mouse brain tissue with FKBP15 antibody at 20 μg/mL.)

Related Product Information for anti-FKBP15 antibody

FKBP15 Antibody: FKBP15, also known as FKBP133, is a member of the FK506-binding protein family, a group of proteins initially identified as immunophilins, targets for the immunosupressant drugs FK506 and Rapamycin. FKBP15 is expressed in the developing nervous system and contains a domain similar to Wiskott-Aldrich syndrome protein homology region 1 (WH1) in addition to the FK506-binding protein motif. FKBP15 is distributed along the axonal shafts and partially co-localizes with F-actin in the growth cones of dorsal root ganglion neurons; overexpression of FKBP15 resulted in the number of filopodia in transfected neurons, suggesting that FKBP15 modulates growth cone behavior. FKBP15 has also been shown to associate with both microtubules and the actin filament systems and disruption of its expression by RNAi resulted in delayed transport of early endosomes in HeLa cells indicating that FKBP15 is also involved in the transport of early endosomes. At least three isoforms of FKBP15 are known to exist.

NCBI and Uniprot Product Information

• NCBI GI #: 150010552
• NCBI GeneID: 23307
• NCBI Accession #: NP_056073
• NCBI GenBank Nucleotide #: NM_015258.1
• UniProt Accession #: Q5T1M5; Q05DK8; Q5T1M2; Q6DD85; Q9Y4D0
• Molecular Weight: 50,330 Da
• NCBI Official Full Name: FK506-binding protein 15
• NCBI Official Synonym Full Names: FK506 binding protein 15, 133kDa
• NCBI Official Symbol: FKBP15
• NCBI Official Synonym Symbols: FKBP133; PPP1R76; KIAA0674
• NCBI Protein Information: FK506-binding protein 15; WAFL; FKBP-15; FKBP-133; 133 kDa FKBP; WASP and FKBP-like protein; FK506-binding protein 133kDa; 133 kDa FK506-binding protein; protein phosphatase 1, regulatory subunit 76
• UniProt Protein Name: FK506-binding protein 15
• Protein Family: FK506-binding protein
• UniProt Gene Name: FKBP15
• UniProt Synonym Gene Names: KIAA0674; FKBP-15; 133 kDa FKBP; FKBP-133; WAFL
• UniProt Entry Name: FKB15_HUMAN

Uniprot Description

FKBP15: May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase. Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule- based movement. Belongs to the FKBP-type PPIase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 9q32

Cellular Component: growth cone; membrane; axon; early endosome; actin filament

Molecular Function: protein binding; actin binding

Biological Process: protein folding; endocytosis