Western Blot (WB)
(Western blot analysis of ZIP6 in mouse lung tissue lysate with ZIP6 antibody at 1 μg/mL.)
Rabbit anti-Human, Mouse ZIP6 Polyclonal Antibody | anti-SLC39A6 antibody
ZIP6 Antibody
Gene Names
SLC39A6; LIV-1
Reactivity
Human, Mouse
Applications
ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
Purity
ZIP6 Antibody is affinity chromatography purified via peptide column.
Synonyms
ZIP6; Polyclonal Antibody; ZIP6 Antibody; LIV-1; LIV1; Zinc transporter ZIP6; Estrogen-regulated protein LIV-1; ZIP-6; solute carrier family 39 (zinc transporter); member 6; anti-SLC39A6 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
ZIP6 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
433
Applicable Applications for anti-SLC39A6 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
ZIP6 antibody can be used for detection of ZIP6 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
Conjugate
Unconjugated
Immunogen
ZIP6 antibody was raised against a 16 amino acid synthetic peptide near the center of human ZIP6.
Buffer
ZIP6 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
ZIP6 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of ZIP6 in mouse lung tissue lysate with ZIP6 antibody at 1 μg/mL.)
Western Blot (WB)
(Western blot analysis of ZIP6 in mouse lung tissue lysate with ZIP6 antibody at 1 μg/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of ZIP6 in mouse lung tissue with ZIP6 antibody at 5 μg/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of ZIP6 in mouse lung tissue with ZIP6 antibody at 5 μg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of ZIP6 in mouse lung tissue with ZIP6 antibody at 20 μg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of ZIP6 in mouse lung tissue with ZIP6 antibody at 20 μg/mL.)
Related Product Information for anti-SLC39A6 antibody
ZIP6 Antibody: The zinc transporter ZIP6, also known as SLC39A6, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP6 was initially identified as LIV-1, an estrogen-regulated gene that has been implicated in metastatic breast cancer. Elevated ZIP6 expression has also been reported in human cervical cancer and the HeLa cell line; down-regulation of ZIP6 expression in HeLa by RNAi inhibited cell proliferation, colony formation, migration and invasiveness, as well as decreasing Snail and Slug levels, suggesting ZIP6 plays a regulatory role on the ERK1/2-Snail/Slug pathway.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
48,605 Da
NCBI Official Full Name
zinc transporter ZIP6 isoform 2
NCBI Official Synonym Full Names
solute carrier family 39 (zinc transporter), member 6
NCBI Official Symbol
SLC39A6
NCBI Official Synonym Symbols
LIV-1
NCBI Protein Information
zinc transporter ZIP6; ZIP-6; zrt- and Irt-like protein 6; estrogen-regulated protein LIV-1; LIV-1 protein, estrogen regulated; solute carrier family 39 member 6; solute carrier family 39 (metal ion transporter), member 6
UniProt Protein Name
Zinc transporter ZIP6
Protein Family
UniProt Gene Name
SLC39A6
UniProt Synonym Gene Names
LIV1; ZIP6; ZIP-6
UniProt Entry Name
S39A6_HUMAN
NCBI Description
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
Uniprot Description
SLC39A6: May act as a zinc-influx transporter. Belongs to the ZIP transporter (TC 2.A.5) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Transporter, SLC family; Transporter; Membrane protein, integral
Chromosomal Location of Human Ortholog: 18q12.2
Cellular Component: cell surface; endoplasmic reticulum; integral to plasma membrane; plasma membrane
Molecular Function: zinc ion transmembrane transporter activity
Biological Process: cellular zinc ion homeostasis; transmembrane transport
Research Articles on SLC39A6
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Product Notes
The SLC39A6 slc39a6 (Catalog #AAA150870) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ZIP6 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's ZIP6 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). ZIP6 antibody can be used for detection of ZIP6 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL. Researchers should empirically determine the suitability of the SLC39A6 slc39a6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ZIP6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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