Western Blot (WB)
(Western blot analysis of FKBP10 expression in HeLa (A), mouse kidney (B), mouse heart (C) whole cell lysates.)
Rabbit anti-Human, Mouse FKBP10 Polyclonal Antibody | anti-FKBP10 antibody
Anti-FKBP10 Antibody
IHC: 1:50-1:200
Western Blot (WB)
(Western blot analysis of FKBP10 expression in HeLa (A), mouse kidney (B), mouse heart (C) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of FKBP10 expression in HeLa (A), mouse kidney (B), mouse heart (C) whole cell lysates.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of FKBP10 staining in human liver cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of FKBP10 staining in human liver cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]
Uniprot Description
FKBP10: PPIases accelerate the folding of proteins during protein synthesis. Defects in FKBP10 are the cause of osteogenesis imperfecta type 6 (OI6). OI6 is a moderate to severe, autosomal recessive form of osteogenesis imperfecta characterized by increased serum alkaline phosphatase levels and bone histology exhibiting a fish scale-like lamellar pattern. Osteogenesis imperfecta defines a group of connective tissue disorders characterized by bone fragility and low bone mass.
Protein type: EC 5.2.1.8; Isomerase
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum lumen
Molecular Function: peptidyl-prolyl cis-trans isomerase activity; FK506 binding; calcium ion binding
Biological Process: protein peptidyl-prolyl isomerization
Disease: Osteogenesis Imperfecta, Type Xi; Bruck Syndrome 1
Research Articles on FKBP10
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Product Notes
The FKBP10 fkbp10 (Catalog #AAA8306676) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-FKBP10 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's FKBP10 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500-1:2000 IHC: 1:50-1:200. Researchers should empirically determine the suitability of the FKBP10 fkbp10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FKBP10, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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