Rabbit anti-Human FGF22 Polyclonal Antibody | anti-FGF22 antibody

FGF22, NT (FGF22, Fibroblast growth factor 22) (MaxLight 405)

Cat. Num. AAA6299027

• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: FGF22; Polyclonal Antibody; NT (FGF22; Fibroblast growth factor 22) (MaxLight 405); Fibroblast growth factor 22; anti-FGF22 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human FGF22.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.

• Applicable Applications for anti-FGF22 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 18-46 in the N-terminal region of human FGF22, UniProt Accession #NP_065688.1; Q9HCT0; Q9ESS2. Species sequence homology: mouse
• Conjugate: MaxLight405
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in MDA-MB231, K562, 293, CEM cell line lysates (35ug/lane)usingMBS6011408. This demonstrates that MBS6011408 detected the FGF22 protein (arrow).)

Related Product Information for anti-FGF22 antibody

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development. [provided by RefSeq].

Product Categories/Family for anti-FGF22 antibody

Antibodies; Growth Factors; Cytokines

References

1. Moffa, A.B., et al. J. Cell. Physiol. 210(3):720-731(2007). 2. Zhang, X., et al. J. Biol. Chem. 281(23):15694-15700(2006). 3. Beer, H.D., et al. Oncogene 24(34):5269-5277(2005). 4. Popovici, C., et al. J. Biol. Chem. 279(38):40146-40152(2004). 5. Umemori, H., et al. Cell 118(2):257-270(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 10190672
• NCBI GeneID: 27006
• NCBI Accession #: NP_065688.1
• NCBI GenBank Nucleotide #: NM_020637.1
• UniProt Accession #: Q9HCT0; Q9ESS2
• Molecular Weight: 19,663 Da
• NCBI Official Full Name: fibroblast growth factor 22
• NCBI Official Synonym Full Names: fibroblast growth factor 22
• NCBI Official Symbol: FGF22
• NCBI Protein Information: fibroblast growth factor 22; FGF-22
• UniProt Protein Name: Fibroblast growth factor 22
• Protein Family: Fibroblast growth factor
• UniProt Gene Name: FGF22
• UniProt Synonym Gene Names: FGF-22
• UniProt Entry Name: FGF22_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development. [provided by RefSeq, Jul 2008]

Uniprot Description

FGF22: Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development. Belongs to the heparin-binding growth factors family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: Golgi apparatus; extracellular space; cell surface; nucleolus; extracellular region

Molecular Function: growth factor activity; fibroblast growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; insulin receptor signaling pathway; innate immune response; cell differentiation