Rabbit FGF-13 Polyclonal Antibody | anti-FGF-13 antibody

FGF-13 (H184) Polyclonal Antibody

Cat. Num. AAA3013881

• Gene Names: FGF13; FGF2; FHF2; FHF-2; FGF-13; LINC00889
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: FGF-13; Polyclonal Antibody; FGF-13 (H184) Polyclonal Antibody; FGF 13; FGF 2; FGF13; FGF2; FHF 2; FHF-2; FHF2; Fibroblast growth factor 13; anti-FGF-13 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: FGF-13 (H184) polyclonal antibody detects endogenous levels of FGF-13 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 199

• Applicable Applications for anti-FGF-13 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding to amino acids 152-200 of Human FGF-13.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of FGF-13 (H184) pAb at 1:500 dilutionLane1:Hela whole cell lysate (40ug) Lane2:U-87MG whole cell lysate (40ug) Lane3:The Brain tissue lysate of Mouse (40ug) Lane4:The Brain tissue lysate of Rat (40ug))

Related Product Information for anti-FGF-13 antibody

Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. Fibroblast growth factor-13 (FGF-13), also known as FHF-2, is involved in nervous system development. The FGF13 gene, mapping by linkage to the q26 region of the human X chromosome, is a candidate gene for the Borjeson-Forssman-Lehmann syndrome (BFLS), an Xlinked mental retardation. It is highly expressed in brain and skeletal muscle.

NCBI and Uniprot Product Information

• NCBI GI #: 213417606
• NCBI GeneID: 2258
• NCBI Accession #: NP_001132970.1
• NCBI GenBank Nucleotide #: NP_001132970.1
• UniProt Accession #: Q92913
• Molecular Weight: ~ 28kDa
• NCBI Official Full Name: fibroblast growth factor 13 isoform 4
• NCBI Official Synonym Full Names: fibroblast growth factor 13
• NCBI Official Symbol: FGF13
• NCBI Official Synonym Symbols: FGF2; FHF2; FHF-2; FGF-13; LINC00889
• NCBI Protein Information: fibroblast growth factor 13
• UniProt Protein Name: Fibroblast growth factor 13
• UniProt Gene Name: FGF13
• UniProt Synonym Gene Names: FHF2; FGF-13; FHF-2
• UniProt Entry Name: FGF13_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked cognitive disability mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini. [provided by RefSeq, Nov 2008]

Uniprot Description

FGF13: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. Belongs to the heparin-binding growth factors family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Nucleolus

Chromosomal Location of Human Ortholog: Xq26.3

Cellular Component: microtubule; neuron projection; growth cone; axon; cytoplasm; dendrite; plasma membrane; extracellular region; nucleolus; nucleus; filopodium

Molecular Function: protein binding; growth factor activity; sodium channel regulator activity; microtubule binding; beta-tubulin binding; protein kinase activator activity

Biological Process: nervous system development; negative regulation of microtubule depolymerization; establishment of neuroblast polarity; hippocampus development; neuron migration; MAPKKK cascade; negative regulation of collateral sprouting; learning; signal transduction; memory; cerebral cortex cell migration; cell-cell signaling; positive regulation of protein kinase activity; microtubule polymerization