Rabbit anti-Human FGD5 Polyclonal Antibody | anti-FGD5 antibody

FGD5 Antibody

Cat. Num. AAA7045672

• Gene Names: FGD5; ZFYVE23
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen Affinity Purified
• Synonyms: FGD5; Polyclonal Antibody; FGD5 Antibody; FYVE; RhoGEF and PH domain-containing protein 5; Zinc finger FYVE domain-containing protein 23; ZFYVE23; anti-FGD5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 1462

• Applicable Applications for anti-FGD5 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: Recommended dilution: IHC: 1:20-1:200
• Species: Human
• Immunogen: Recombinant human FYVE, RhoGEF and PH domain-containing protein 5 protein (C-260AA)
• Conjugate: Non-conjugated
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human gastric cancer using MBS7045672 at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human bladder cancer using MBS7045672 at dilution 1:100)

Related Product Information for anti-FGD5 antibody

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.

NCBI and Uniprot Product Information

• NCBI GI #: 194018497
• NCBI GeneID: 152273
• NCBI Accession #: NP_689749.3
• NCBI GenBank Nucleotide #: NM_152536.3
• UniProt Accession #: Q6ZNL6; Q6MZY1; Q7Z303; Q8IYP3; Q8N861; Q8N8G4; B3KVQ3
• Molecular Weight: 61,238 Da
• NCBI Official Full Name: FYVE, RhoGEF and PH domain-containing protein 5 isoform 1
• NCBI Official Synonym Full Names: FYVE, RhoGEF and PH domain containing 5
• NCBI Official Symbol: FGD5
• NCBI Official Synonym Symbols: ZFYVE23
• NCBI Protein Information: FYVE, RhoGEF and PH domain-containing protein 5
• UniProt Protein Name: FYVE, RhoGEF and PH domain-containing protein 5
• Protein Family: FYVE, RhoGEF and PH domain-containing protein
• UniProt Gene Name: FGD5
• UniProt Synonym Gene Names: ZFYVE23
• UniProt Entry Name: FGD5_HUMAN

Uniprot Description

FGD5: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rac/Rho

Chromosomal Location of Human Ortholog: 3p25.1

Cellular Component: cytoplasm; Golgi apparatus; lamellipodium; ruffle

Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; small GTPase binding

Biological Process: actin cytoskeleton organization and biogenesis; cytoskeleton organization and biogenesis; filopodium formation; regulation of cell shape; regulation of GTPase activity