Rabbit anti-Human FFAR2 Polyclonal Antibody | anti-FFAR2 antibody

FFAR2 Antibody; Biotin conjugated

Cat. Num. AAA7003110

• Gene Names: FFAR2; FFA2R; GPR43
• Reactivity: Human
• Applications: ELISA
• Purity: >95%,Protein G purified
• Synonyms: FFAR2; Polyclonal Antibody; FFAR2 Antibody; Biotin conjugated; Free fatty acid receptor 2; G-protein coupled receptor 43; FFA2; GPCR43; GPR43; anti-FFAR2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%,Protein G purified
• Form/Format: Liquid
• Sequence Length: 330

• Applicable Applications for anti-FFAR2 antibody: ELISA (EIA)
• Immunogen: Recombinant human Free fatty acid receptor 2 protein
• Conjugation: Biotin
• Storage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-28420 / sc-28421 / sc-28423 / sc-32906
• Preparation and Storage: Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.

Related Product Information for anti-FFAR2 antibody

G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes (PubMed:21037097). Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably acetate, propionate and butyrate (PubMed:12496283, PubMed:12711604). Exhibits a SCFA-independent constitutive G protein-coupled receptor activity (PubMed:23066016).

NCBI and Uniprot Product Information

• NCBI GI #: 4885333
• NCBI GeneID: 2867
• NCBI Accession #: NP_005297.1
• NCBI GenBank Nucleotide #: NM_005306.2
• UniProt Accession #: O15552; Q4VAZ3; Q4VAZ5; Q4VBL5; B0M0J9
• Molecular Weight: 37,144 Da
• NCBI Official Full Name: free fatty acid receptor 2
• NCBI Official Synonym Full Names: free fatty acid receptor 2
• NCBI Official Symbol: FFAR2
• NCBI Official Synonym Symbols: FFA2R; GPR43
• NCBI Protein Information: free fatty acid receptor 2
• UniProt Protein Name: Free fatty acid receptor 2
• Protein Family: Free fatty acid receptor
• UniProt Gene Name: FFAR2
• UniProt Synonym Gene Names: FFA2; GPCR43; GPR43
• UniProt Entry Name: FFAR2_HUMAN

NCBI Description

This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels. [provided by RefSeq, Apr 2009]

Uniprot Description

FFAR2: Receptor for short chain fatty acids through a G(i)- protein-mediated inhibition of adenylyl cyclase and elevation of intracellular calcium. The rank order of potency for agonists of this receptor is acetate= propionate = butyrate > pentanoate = formate. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: cell projection; integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; lipid binding; protein binding

Biological Process: cell surface pattern recognition receptor signaling pathway; fat cell differentiation; G-protein coupled receptor protein signaling pathway; glucose homeostasis; leukocyte chemotaxis during inflammatory response; mucosal immune response; positive regulation of acute inflammatory response to non-antigenic stimulus; positive regulation of chemokine production; positive regulation of cytokine production during immune response; regulation of acute inflammatory response; sequestering of lipid