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Western Blot (WB) (Western blot analysis of FEZ1 in SK-N-SH cell lysate with FEZ1 antibody at 1 ug/mL in the (A) presence and (B) absence of blocking peptide.)

Rabbit FEZ1 Polyclonal Antibody | anti-FEZ1 antibody

FEZ1 Antibody

Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot
Purity
Affinity chromatography purified via peptide column
Synonyms
FEZ1; Polyclonal Antibody; FEZ1 Antibody; Fasciculation and elongation protein zeta 1; zygin 1; anti-FEZ1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
392
Applicable Applications for anti-FEZ1 antibody
ELISA (EIA), Western Blot (WB)
Immunogen Type
Peptide
Immunogen Description
Raised against a 19 amino acid peptide from near the carboxy terminus of human FEZ1.
Target Name
FEZ1
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of FEZ1 in SK-N-SH cell lysate with FEZ1 antibody at 1 ug/mL in the (A) presence and (B) absence of blocking peptide.)

Western Blot (WB) (Western blot analysis of FEZ1 in SK-N-SH cell lysate with FEZ1 antibody at 1 ug/mL in the (A) presence and (B) absence of blocking peptide.)
Related Product Information for anti-FEZ1 antibody
Similar to its C. elegans homolog UNC-76, mammalian FEZ1, an abundant membrane protein and protein kinase C (PKC)-Z substrate, is involved in axonal guidance. Following phosphorylation by PKC-Z, FEZ1 translocates from the plasma membrane to the cytoplasm. FEZ1 is then able to interact with a number of proteins involved in axonal outgrowth and cellular transport such as DISC1, a candidate gene for schizophrenia, as well as kinesin-1, a microtubule-based motor protein. FEZ1 also interacts with proteins involved in transcriptional regulation and chromatin remodeling, suggesting that FEZ1 may have nuclear regulatory functions in addition to those for neuronal development. At least two distinct isoforms of FEZ1 are known to exist.
Product Categories/Family for anti-FEZ1 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
12,074 Da
NCBI Official Full Name
fasciculation and elongation protein zeta-1 isoform 1
NCBI Official Synonym Full Names
fasciculation and elongation protein zeta 1 (zygin I)
NCBI Official Symbol
FEZ1
NCBI Protein Information
fasciculation and elongation protein zeta-1
UniProt Protein Name
Fasciculation and elongation protein zeta-1
UniProt Gene Name
FEZ1
UniProt Entry Name
FEZ1_HUMAN

NCBI Description

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

FEZ1: May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules. Belongs to the zygin family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 11q24.2

Cellular Component: microtubule cytoskeleton; centrosome; microtubule; mitochondrion; axon; cytoplasm; dendrite; plasma membrane

Molecular Function: protein binding; gamma-tubulin binding; protein kinase C binding; protein N-terminus binding

Biological Process: establishment of mitochondrion localization; nervous system development; axon guidance; transport; cell adhesion

Research Articles on FEZ1

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Product Notes

The FEZ1 fez1 (Catalog #AAA9403852) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FEZ1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's FEZ1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the FEZ1 fez1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FEZ1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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