FEZ1 blocking peptide

FEZ1 Peptide

Cat. Num. AAA152837

• Applications: Blocking (BL)
• Synonyms: FEZ1; FEZ1 Peptide; Fasciculation and elongation protein zeta-1; Zygin I; fasciculation and elongation protein zeta 1 (zygin I); FEZ1 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 392

• Applicable Applications for FEZ1 blocking peptide: Blocking (BL)
• Application Notes: FEZ1 peptide is used for blocking the activity of FEZ1 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 19 amino acids near the carboxy terminus of human FEZ1.
• Preparation and Storage: Store FEZ1 peptide at -20 degree C, stable for one year.

Western Blot (WB)

(Western blot analysis of FEZ1 in SK-N-SH cell lysate with FEZ1 antibody at 1 μg/mL in the (A) presence and (B) absence of blocking peptide.)

NCBI and Uniprot Product Information

• NCBI GI #: 13431526
• NCBI GeneID: 9638
• UniProt Accession #: Q99689; O00679; O00728; Q6IBI7
• Molecular Weight: 12,074 Da
• NCBI Official Full Name: Fasciculation and elongation protein zeta-1
• NCBI Official Synonym Full Names: fasciculation and elongation protein zeta 1 (zygin I)
• NCBI Official Symbol: FEZ1
• NCBI Protein Information: fasciculation and elongation protein zeta-1; zygin I; zygin-1
• UniProt Protein Name: Fasciculation and elongation protein zeta-1
• Protein Family: Fasciculation and elongation protein
• UniProt Gene Name: FEZ1
• UniProt Entry Name: FEZ1_HUMAN

NCBI Description

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

FEZ1: May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules. Belongs to the zygin family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 11q24.2

Cellular Component: microtubule cytoskeleton; centrosome; microtubule; mitochondrion; axon; cytoplasm; dendrite; plasma membrane

Molecular Function: protein binding; gamma-tubulin binding; protein kinase C binding; protein N-terminus binding

Biological Process: establishment of mitochondrion localization; axon guidance; nervous system development; transport; cell adhesion