Western Blot (WB)
(Anti-FBXO45 Antibody (N-Term)at 1:2000 dilution + HT-1080 whole cell lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilutionPredicted band size : 31 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Rabbit anti-Human FBXO45 Polyclonal Antibody | anti-FBXO45 antibody
FBXO45 Antibody (N-Term)
Western Blot (WB)
(Anti-FBXO45 Antibody (N-Term)at 1:2000 dilution + HT-1080 whole cell lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilutionPredicted band size : 31 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Western Blot (WB)
(Anti-FBXO45 Antibody (N-Term)at 1:2000 dilution + HT-1080 whole cell lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilutionPredicted band size : 31 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Jin J.,et al.Genes Dev. 18:2573-2580(2004).
Gauci S.,et al.Anal. Chem. 81:4493-4501(2009).
NCBI and Uniprot Product Information
NCBI Description
Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (summary by Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Jan 2011]
Uniprot Description
FBXO45: Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration. Plays a role in the regulation of neurotransmission at mature neurons. May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway. Specifically recognizes TP73, promoting its ubiquitination and degradation. Belongs to the FBXO45/Fsn family.
Chromosomal Location of Human Ortholog: 3q29
Cellular Component: presynaptic membrane; postsynaptic membrane; postsynaptic density; cell junction
Molecular Function: protein binding
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; anterior commissure morphogenesis; cerebral cortex tangential migration; protein ubiquitination during ubiquitin-dependent protein catabolic process; neuron migration; protein ubiquitination; cerebral cortex radially oriented cell migration; corticospinal tract morphogenesis; response to DNA damage stimulus
Research Articles on FBXO45
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Product Notes
The FBXO45 fbxo45 (Catalog #AAA9200721) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FBXO45 Antibody (N-Term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FBXO45 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:2000. Researchers should empirically determine the suitability of the FBXO45 fbxo45 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FBXO45, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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