Rabbit anti-Human FBXO31 Polyclonal Antibody | anti-FBXO31 antibody

FBXO31 Antibody

Cat. Num. AAA9409538

• Gene Names: FBXO31; FBX14; Fbx31; MRT45; FBXO14; pp2386
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: FBXO31; Polyclonal Antibody; FBXO31 Antibody; FBX14; Fbx31; FBXO14; pp2386; anti-FBXO31 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total FBXO31 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 2.8 mg/ml (varies by lot)
• Sequence Length: 367

• Applicable Applications for anti-FBXO31 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:50-1:200
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to residues near the C terminal of human F-box protein 31
• Target Name: FBXO31
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using at dilution 1/40.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/40.)

Related Product Information for anti-FBXO31 antibody

This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants.

Product Categories/Family for anti-FBXO31 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 544186107
• NCBI GeneID: 79791
• NCBI Accession #: NP_001269612.1
• NCBI GenBank Nucleotide #: NM_001282683.1
• UniProt Accession #: Q5XUX0; Q5K680; Q8WYV1; Q96D73; Q9UFV4
• Molecular Weight: 49,039 Da
• NCBI Official Full Name: F-box only protein 31 isoform 2
• NCBI Official Synonym Full Names: F-box protein 31
• NCBI Official Symbol: FBXO31
• NCBI Official Synonym Symbols: FBX14; Fbx31; MRT45; FBXO14; pp2386
• NCBI Protein Information: F-box only protein 31
• UniProt Protein Name: F-box only protein 31
• Protein Family: F-box only protein
• UniProt Gene Name: FBXO31
• UniProt Synonym Gene Names: FBX14; FBX31
• UniProt Entry Name: FBX31_HUMAN

NCBI Description

This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Uniprot Description

FBXO31: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. Part of a SCF (SKP1-cullin-F-box) protein ligase complex. By DNA damage. Increases after UV irradiation, X-ray irradiation, oxidative stress (H(2)O(2)) or addition of the chemotherapeutic DNA-damaging agents etoposide, adriamycin, cisplatin or fluorouracil. Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow. Belongs to the FBXO31 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; Cell cycle regulation

Chromosomal Location of Human Ortholog: 16q24.2

Cellular Component: cell soma; SCF ubiquitin ligase complex

Molecular Function: cyclin binding

Biological Process: G1 DNA damage checkpoint; cyclin catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; response to DNA damage stimulus

Disease: Mental Retardation, Autosomal Recessive 45