Rabbit anti-Human, Mouse FBXL12 Polyclonal Antibody | anti-FBXL12 antibody

FBXL12 antibody

Cat. Num. AAA9411001

• Gene Names: FBXL12; Fbl12
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry
• Purity: Purified by antigen-affinity chromatography.
• Synonyms: FBXL12; Polyclonal Antibody; FBXL12 antibody; anti-FBXL12 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Purity/Purification: Purified by antigen-affinity chromatography.
• Form/Format: Supplied in 1XPBS, 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
• Sequence Length: 326

• Applicable Applications for anti-FBXL12 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Western blotting: 1:500-1:3000; Immunohistochemistry: 1:50-1:500
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide contain a sequence corresponding to a region within amino acids 265 and 326 of FBXL12
• Target Name: FBXL12
• Preparation and Storage: Store at -20 degree C for long term preservation (recommended). Store at 4 degree C for short term use.

Testing Data

(Sample (30 ug of whole cell lysate) A: Hep G2 10% SDS PAGE Primary antibody diluted at 1: 1000)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded SW480 xenograft, using FBXL12 antibody at 1: 500 dilution.)

Related Product Information for anti-FBXL12 antibody

Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM]

Product Categories/Family for anti-FBXL12 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 8923179
• NCBI GeneID: 54850
• NCBI Accession #: NP_060173
• NCBI GenBank Nucleotide #: NM_017703.1
• Molecular Weight: 30,491 Da
• NCBI Official Full Name: F-box/LRR-repeat protein 12
• NCBI Official Synonym Full Names: F-box and leucine-rich repeat protein 12
• NCBI Official Symbol: FBXL12
• NCBI Official Synonym Symbols: Fbl12
• NCBI Protein Information: F-box/LRR-repeat protein 12
• UniProt Protein Name: F-box/LRR-repeat protein 12
• UniProt Gene Name: FBXL12
• UniProt Synonym Gene Names: FBL12
• UniProt Entry Name: FXL12_HUMAN

NCBI Description

Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Uniprot Description

FBXL12: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: cytoplasm; ubiquitin ligase complex

Molecular Function: protein binding

Biological Process: ubiquitin-dependent protein catabolic process; protein ubiquitination