Rabbit anti-Human FBXL12 Polyclonal Antibody | anti-FBXL12 antibody

FBXL12, CT (FBXL12, FBL12, F-box/LRR-repeat protein 12, F-box and leucine-rich repeat protein 12, F-box protein FBL12) (APC)

Cat. Num. AAA6298220

• Gene Names: FBXL12; Fbl12
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: FBXL12; Polyclonal Antibody; CT (FBXL12; FBL12; F-box/LRR-repeat protein 12; F-box and leucine-rich repeat protein 12; F-box protein FBL12) (APC); F-box protein FBL12; anti-FBXL12 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-FBXL12 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: FBXL12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-304 amino acids from the C-terminal region of human FBXL12.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(FBXL12 Antibody (C-term) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the FBXL12 antibody detected the FBXL12 protein (arrow).)

Related Product Information for anti-FBXL12 antibody

Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM].

Product Categories/Family for anti-FBXL12 antibody

Antibodies; Ubiquitin Ligases

References

Lamesch, P., et al. Genomics 89(3):307-315(2007). Barrios-Rodiles, M., et al. Science 307(5715):1621-1625(2005). Jin, J., et al. Genes Dev. 18(21):2573-2580(2004). Winston, J.T., et al. Curr. Biol. 9(20):1180-1182(1999).

NCBI and Uniprot Product Information

• NCBI GI #: 8923179
• NCBI GeneID: 54850
• NCBI Accession #: NP_060173.1
• NCBI GenBank Nucleotide #: NM_017703.2
• UniProt Accession #: Q9NXK8; Q9H5K4; B3KSJ8
• Molecular Weight: 30,491 Da
• NCBI Official Full Name: F-box/LRR-repeat protein 12 isoform a
• NCBI Official Synonym Full Names: F-box and leucine-rich repeat protein 12
• NCBI Official Symbol: FBXL12
• NCBI Official Synonym Symbols: Fbl12
• NCBI Protein Information: F-box/LRR-repeat protein 12
• UniProt Protein Name: F-box/LRR-repeat protein 12
• UniProt Gene Name: FBXL12
• UniProt Synonym Gene Names: FBL12
• UniProt Entry Name: FXL12_HUMAN

NCBI Description

Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]