Immunohistochemistry (IHC)
(MBS420571 (5ug/ml) staining of paraffin embedded Human Skin. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.)
Goat FBXL10/PCCX2 Polyclonal Antibody | anti-KDM2B antibody
Goat anti-FBXL10/PCCX2 Antibody
IHC: Paraffin embedded Human Skin. Recommended concentration: 5ug/ml.
Immunohistochemistry (IHC)
(MBS420571 (5ug/ml) staining of paraffin embedded Human Skin. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.)
Immunohistochemistry (IHC)
(MBS420571 (5ug/ml) staining of paraffin embedded Human Skin. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
FBXL10: Histone demethylase that demethylates 'Lys-4' and 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Belongs to the JHDM1 histone demethylase family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.14.11.27; DNA-binding; Oxidoreductase; Demethylase; Nucleolus
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component: nucleolus; nucleoplasm; nucleus; PcG protein complex
Molecular Function: DNA binding; histone demethylase activity; histone demethylase activity (H3-K36 specific); protein binding; rRNA binding; zinc ion binding
Biological Process: embryonic camera-type eye morphogenesis; forebrain development; fourth ventricle development; hindbrain development; initiation of neural tube closure; lateral ventricle development; midbrain development; midbrain-hindbrain boundary morphogenesis; negative regulation of neuron apoptosis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell growth; spermatogenesis; third ventricle development; transcription, DNA-dependent
Research Articles on KDM2B
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Product Notes
The KDM2B kdm2b (Catalog #AAA420571) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-FBXL10/PCCX2 Antibody reacts with Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog and may cross-react with other species as described in the data sheet. AAA Biotech's FBXL10/PCCX2 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA, Immunohistochemistry (IHC). Peptide ELISA: Antibody detection limit dilution 1: 32000. IHC: Paraffin embedded Human Skin. Recommended concentration: 5ug/ml. Researchers should empirically determine the suitability of the KDM2B kdm2b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FBXL10/PCCX2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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