Rabbit anti-Human, Mouse FBLN2 Polyclonal Antibody | anti-FBLN2 antibody

FBLN2 Polyclonal Antibody

Cat. Num. AAA3007315

• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: FBLN2; Polyclonal Antibody; FBLN2 Polyclonal Antibody; Fibulin-2; FIBL-2; anti-FBLN2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: FBLN2 polyclonal antibody detects endogenous levels of FBLN2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 1231

• Applicable Applications for anti-FBLN2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human FBLN2.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of FBLN2 polyclonal antibody at 1:500 dilution Line1:Hela whole cell lysateLine2:Raw264. 7 whole cell lysate)

Related Product Information for anti-FBLN2 antibody

Fibulin-1 and Fibulin-2 associate with Fibronectin and other extracellular matrix proteins. In bone marrow, Fibulin-1 and Fibulin-2 bind to Fibronectin in the adherent layer. Fibulin-1 expression is stimulated by estrogen in ovarian cancer cell lines and has been suggested as both an agent of metastasis in ovarian cancer cells and as an indicator for predicting cancer risk or aggressiveness in ovarian carcinomas. The mobility of cancer cells may be inhibited with increasing exposure to Fibulin-1. Fibulin-2 binds to the lectin domains of extracellular matrix proteins aggrecan, versican and brevican. Fibulin-2 is abundantly expressed in heart, placenta and ovarian tissue, where it localizes to basement membranes and connective tissue compartments. In mice, differential Fibulin-2 gene expression correlates with the early phase of diabetic kidneys and glomerulosclerosis. The gene encoding human Fibulin-2 maps to chromosome 3p25.1.

NCBI and Uniprot Product Information

• NCBI GI #: 51873053
• NCBI GeneID: 2199
• NCBI Accession #: NP_001004019.1
• NCBI GenBank Nucleotide #: NP_001004019.1
• UniProt Accession #: P98095
• Molecular Weight: ~ 127kDa
• NCBI Official Full Name: fibulin-2 isoform a
• NCBI Official Synonym Full Names: fibulin 2
• NCBI Official Symbol: FBLN2
• NCBI Protein Information: fibulin-2
• UniProt Protein Name: Fibulin-2
• Protein Family: Fibulin
• UniProt Gene Name: FBLN2
• UniProt Synonym Gene Names: FIBL-2
• UniProt Entry Name: FBLN2_HUMAN

NCBI Description

This gene encodes an extracellular matrix protein, which belongs to the fibulin family. This protein binds various extracellular ligands and calcium. It may play a role during organ development, in particular, during the differentiation of heart, skeletal and neuronal structures. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

FBLN2: Its binding to fibronectin and some other ligands is calcium dependent. Belongs to the fibulin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3p25.1

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular region; vesicle

Molecular Function: extracellular matrix binding; extracellular matrix structural constituent; calcium ion binding

Biological Process: extracellular matrix organization and biogenesis