Western Blot (WB)
(FBLIM1 Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the FBLIM1 antibody detected the FBLIM1 protein (arrow).)
Rabbit anti-Human FBLIM1 Polyclonal Antibody | anti-FBLIM1 antibody
FBLIM1 Antibody (C-term)
Western Blot (WB)
(FBLIM1 Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the FBLIM1 antibody detected the FBLIM1 protein (arrow).)
Western Blot (WB)
(FBLIM1 Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the FBLIM1 antibody detected the FBLIM1 protein (arrow).)
Immunohistochemistry (IHC)
(FBLIM1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FBLIM1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(FBLIM1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FBLIM1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
filamin-binding domain, a central proline-rich domain, and,
multiple C-terminal LIM domains. This protein localizes at cell
junctions and may link cell adhesion structures to the actin
cytoskeleton. This protein may be involved in the assembly and
stabilization of actin-filaments and likely plays a role in
modulating cell adhesion, cell morphology and cell motility. This
protein also localizes to the nucleus and may affect cardiomyocyte
differentiation after binding with the CSX/NKX2-5 transcription
factor. Alternative splicing results in multiple transcript
variants encoding different isoforms.
Ithychanda, S.S., et al. J. Biol. Chem. 284(7):4713-4722(2009)
Lad, Y., et al. J. Biol. Chem. 283(50):35154-35163(2008)
Lai-Cheong, J.E., et al. J. Invest. Dermatol. 128(9):2156-2165(2008)
Papachristou, D.J., et al. Histopathology 51(4):499-508(2007)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
FBLIM1: Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin- containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1p36.21
Cellular Component: focal adhesion; stress fiber; cell cortex; cytosol
Molecular Function: zinc ion binding; filamin binding
Biological Process: regulation of cell shape; cell-cell adhesion; regulation of integrin activation
Research Articles on FBLIM1
Similar Products
Product Notes
The FBLIM1 fblim1 (Catalog #AAA9201745) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 294-323. The FBLIM1 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FBLIM1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the FBLIM1 fblim1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FBLIM1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
