Rabbit Fatty Acid Binding Protein, Liver Polyclonal Antibody | anti-FABP7 antibody

Fatty Acid Binding Protein, Liver (Liver-type Fatty Acid-binding Protein, L-FABP, Fatty Acid-binding Protein 1, FABP1, Fabplg, MGC108756, p14, RATFABPLG, Squalene- and Sterol-carrier Protein, SCP, Z-protein)

Cat. Num. AAA623619

• Gene Names: FABP7; MRG; BLBP; FABPB; B-FABP; DKFZp547J2313
• Reactivity: Human, Mouse, Porcine, Rat
• Applications: ELISA, Western Blot, Immunoprecipitation
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: Fatty Acid Binding Protein; Liver; Polyclonal Antibody; Liver (Liver-type Fatty Acid-binding Protein; L-FABP; Fatty Acid-binding Protein 1; FABP1; Fabplg; MGC108756; p14; RATFABPLG; Squalene- and Sterol-carrier Protein; SCP; Z-protein); Anti -Fatty Acid Binding Protein; anti-FABP7 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Porcine, Rat
• Clonality: Polyclonal
• Specificity: Recognizes rat L-FABP of both natural and recombinant origin. No cross-reactivities with other FABP types have been detected. Species Crossreactivity: Human, porcine, mouse
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.

• Applicable Applications for anti-FABP7 antibody: ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: Suitable for use in Immunoprecipitation, ELISA and Western Blot.
• Immunogen: Rat Fatty Acid Binding Protein, Liver
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-FABP7 antibody

Liver FABP is localized in hepatocytes and brush cells found in the biliary tract. Localization of FABP is demonstrated in mucosa of small and large intestine and in intestinal metaplasia of the gastric mucosa. Fatty acid binding proteins (FABP) are small (~13-14kD) intracellulair proteins with a high degree of tissue specificity. FABPs are a class of cytoplasmic proteins that bind long chain fatty acids. They are abundantly present in various cell types and seem to play an important role in the intracellular utilization of fatty acids. There are at least six distinct types of FABP, each showing a specific pattern of tissue expression. FABP leaks due to its small size rapidly out of ischemically damaged dying cells leading to a rise in serum levels. Liver FABP is a sensitive marker for cell damage of liver cells in vitro and vivo. Ischemically damaged tissues are characterized histological by absence (or low presence) of FABP facilitating recognition of such areas. Next to this L-FABP is a marker for rapid hepatocyte lysis in vitro (as for example in toxicology assays) and for detection of liver damage during and after transplantation.

Product Categories/Family for anti-FABP7 antibody

Antibodies; Abs to Fatty Acid Binding Protein

NCBI and Uniprot Product Information

• NCBI GI #: 2645203
• NCBI GeneID: 2173
• UniProt Accession #: O15540; O14951; Q6IAU7; B2R4L1; Q9H047
• Molecular Weight: 14,889 Da
• NCBI Official Full Name: fatty acid binding protein
• NCBI Official Synonym Full Names: fatty acid binding protein 7, brain
• NCBI Official Symbol: FABP7
• NCBI Official Synonym Symbols: MRG; BLBP; FABPB; B-FABP; DKFZp547J2313
• NCBI Protein Information: fatty acid-binding protein, brain; OTTHUMP00000017118; OTTHUMP00000017119; brain lipid binding protein; brain lipid-binding protein; fatty acid-binding protein 7; brain-type fatty acid-binding protein; mammary-derived growth inhibitor related; mammary-derived growth inhibitor-related
• UniProt Protein Name: Fatty acid-binding protein, brain
• Protein Family: Fatty acid-binding protein
• UniProt Gene Name: FABP7
• UniProt Synonym Gene Names: BLBP; FABPB; MRG
• UniProt Entry Name: FABP7_HUMAN

NCBI Description

The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism. [provided by RefSeq]

Uniprot Description

FABP7: B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Protein type: Lipid-binding; Cell development/differentiation; Cell cycle regulation

Chromosomal Location of Human Ortholog: 6q22-q23

Cellular Component: cell projection; cell soma; cytoplasm; nucleus

Molecular Function: transporter activity; lipid binding

Biological Process: negative regulation of cell proliferation; nervous system development; epithelial cell proliferation; neurogenesis; prepulse inhibition; transport; cell proliferation in forebrain