Western Blot (WB)
(FARP1 Antibody (N-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the FARP1 antibody detected the FARP1 protein (arrow).)
Rabbit anti-Human FARP1 Polyclonal Antibody | anti-FARP1 antibody
FARP1, NT (FARP1, CDEP, PLEKHC2, FERM, RhoGEF and pleckstrin domain-containing protein 1, Chondrocyte-derived ezrin-like protein, Pleckstrin homology domain-containing family C member 2)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Western Blot (WB)
(FARP1 Antibody (N-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the FARP1 antibody detected the FARP1 protein (arrow).)
Western Blot (WB)
(FARP1 Antibody (N-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the FARP1 antibody detected the FARP1 protein (arrow).)
NCBI and Uniprot Product Information
NCBI Description
This gene was originally isolated through subtractive hybridization due to its increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes. The resulting protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain. It is believed to be a member of the band 4.1 superfamily whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses
By similarity.
Subunit structure: Interacts with CADM1. Interacts with RAC1
By similarity.
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction › synapse. Cell junction › synapse › synaptosome
By similarity. Cytoplasm › cytosol
By similarity. Cell projection › filopodium
By similarity. Cell projection › dendrite
By similarity. Cell projection › dendritic spine
By similarity. Note: Recruited to the cell membrane via interaction with CADM1
By similarity.
Tissue specificity: Detected in cAMP-treated chondrocytes, but not in untreated chondrocytes. Detected in fetal brain, heart and spleen, and in adult testis, kidney and lung. Ref.1
Induction: Up-regulated in response to cAMP in cultured embryonic chondrocytes. Ref.1
Domain: Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an autoinhibited conformation. Ref.13
Sequence similarities: Contains 1 DH (DBL-homology) domain.Contains 1 FERM domain.Contains 2 PH domains.
Research Articles on FARP1
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Product Notes
The FARP1 farp1 (Catalog #AAA649297) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FARP1, NT (FARP1, CDEP, PLEKHC2, FERM, RhoGEF and pleckstrin domain-containing protein 1, Chondrocyte-derived ezrin-like protein, Pleckstrin homology domain-containing family C member 2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FARP1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the FARP1 farp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FARP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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