Rabbit anti-Human, Mouse FANCC Polyclonal Antibody | anti-FANCC antibody

Rabbit Polyclonal to Human FANCC

Cat. Num. AAA243340

• Gene Names: FANCC; FA3; FAC; FACC
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: FANCC; Polyclonal Antibody; Rabbit Polyclonal to Human FANCC; Anti-FANCC Antibody IHC-plus; FAC; Fanconi anemia group C protein; FA3; Protein FACC; FACC; Human FANCC; anti-FANCC antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: Human and mouse FANCC.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: 0.1 M Tris-glycine, pH 7, 10% Glycerol, 0.01% Thimerosal
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 558

• Applicable Applications for anti-FANCC antibody: Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB)
• Application Notes: ICC, IF (1:100 - 1:200), IHC-P (10 ug/ml), WB (1:500 - 1:3000)
• Target Species: Human
• Immunogen Description: Recombinant protein fragment containing a sequence corresponding to a region within amino acids 1 and 275 of FANCC.
• Immunogen Type: Recombinant protein
• Immunogen: FANCC antibody was raised against recombinant protein fragment containing a sequence corresponding to a region within amino acids 1 and 275 of FANCC.
• Preparation and Storage: Aliquot and store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-FANCC antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Immunohistochemistry (IHC)

(Anti-FANCC antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Immunofluorescence (IF)

(Immunofluorescence of paraformaldehyde-fixed HeLa, using FANCC antibody at 1:200 dilution.)

Western Blot (WB)

(Sample (30 ug of whole cell lysate). A: H1299. 7.5% SDS PAGE. FANCC antibody diluted at 1:1000)

Western Blot (WB)

(Sample (30 ug of whole cell lysate). A: NIH-3T3. 7.5% SDS PAGE. FANCC antibody. FANCC antibody diluted at 1:1000.)

Related Product Information for anti-FANCC antibody

The function of FANCC is unknown but defects in this gene have been associated with Fanconi anemia.

NCBI and Uniprot Product Information

• NCBI GI #: 56118236
• NCBI GeneID: 2176
• NCBI Accession #: NP_000127.2
• NCBI GenBank Nucleotide #: NM_000136.2
• UniProt Accession #: Q00597; B1ALR8
• Molecular Weight: 63,429 Da
• NCBI Official Full Name: Fanconi anemia group C protein isoform a
• NCBI Official Synonym Full Names: Fanconi anemia, complementation group C
• NCBI Official Symbol: FANCC
• NCBI Official Synonym Symbols: FA3; FAC; FACC
• NCBI Protein Information: Fanconi anemia group C protein
• UniProt Protein Name: Fanconi anemia group C protein
• Protein Family: Fanconi anemia group C protein
• UniProt Gene Name: FANCC
• UniProt Synonym Gene Names: FAC; FACC; Protein FACC
• UniProt Entry Name: FANCC_HUMAN

NCBI Description

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C. [provided by RefSeq, Jul 2008]

Uniprot Description

FANCC: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. Defects in FANCC are the cause of Fanconi anemia complementation group C (FANCC). A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.

Chromosomal Location of Human Ortholog: 9q22.3

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol

Molecular Function: protein binding

Biological Process: removal of superoxide radicals; nucleotide-excision repair; myeloid cell homeostasis; protein complex assembly; DNA repair; germ cell development

Disease: Fanconi Anemia, Complementation Group C; Tracheoesophageal Fistula With Or Without Esophageal Atresia