Rabbit anti-Human FANCC Polyclonal Antibody | anti-FANCC antibody

FANCC (Fanconi Anemia Group C Protein, Protein FACC, FAC, FACC) (AP)

Cat. Num. AAA6378097

• Gene Names: FANCC; FA3; FAC; FACC
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: FANCC; Polyclonal Antibody; FANCC (Fanconi Anemia Group C Protein; Protein FACC; FAC; FACC) (AP); anti-FANCC antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human FANCC.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-FANCC antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human FANCC, aa1-558 (NP_000127.2).
• Immunogen Sequence: MAQDSVDLSCDYQFWMQKLSVWDQASTLETQQDTCLHVAQFQEFLRKMYEALKEMDSNTVIERFPTIGQLLAKACWNPFILAYDESQKILIWCLCCLINKEPQNSGQSKLNSWIQGVLSHILSALRFDKEVALFTQGLGYAPIDYYPGLLKNMVLSLASELRENHLNGFNTQRRMAPERVASLSRVCVPLITLTDVDPLVEALLICHGREPQEILQPEFFEAVNEAILLKKISLPMSAVVCLWLRHLPSLEKAMLHLFEKLISSERNCLRRIECFIKDSSLPQAACHPAIFRVVDEMFRCALLETDGALEIIATIQVFTQCFVEALEKASKQLRFALKTYFPYTSPSLAMVLLQDPQDIPRGHWLQTLKHISELLREAVEDQTHGSCGGPFESWFLFIHFGGWAEMVAEQLLMSAAEPPTALLWLLAFYYGPRDGRQQRAQTMVQVKAVLGHLLAMSRSSSLSAQDLQTVAGQGTDTDLRAPAQQLIRHLLLNFLLWAPGGHTIAWDVITLMAHTAEITHEIIGFLDQTLYRWNRLGIESPRSEKLARELLKELRTQV
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(FANCC rabbit polyclonal antibody. Western Blot analysis of FANCC expression in human kidney.)

Western Blot (WB)

(Western Blot analysis of FANCC expression in transfected 293T cell line by FANCC polyclonal antibody. Lane 1: FANCC transfected lysate (63.4kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-FANCC antibody

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C.

Product Categories/Family for anti-FANCC antibody

Antibodies; DNA Repair/Damage

NCBI and Uniprot Product Information

• NCBI GI #: 56118236
• NCBI GeneID: 2176
• NCBI Accession #: NP_000127.2
• NCBI GenBank Nucleotide #: NM_000136.2
• UniProt Accession #: Q00597; B1ALR8
• Molecular Weight: 63,429 Da
• NCBI Official Full Name: Fanconi anemia group C protein isoform a
• NCBI Official Synonym Full Names: Fanconi anemia, complementation group C
• NCBI Official Symbol: FANCC
• NCBI Official Synonym Symbols: FA3; FAC; FACC
• NCBI Protein Information: Fanconi anemia group C protein
• UniProt Protein Name: Fanconi anemia group C protein
• Protein Family: Fanconi anemia group C protein
• UniProt Gene Name: FANCC
• UniProt Synonym Gene Names: FAC; FACC; Protein FACC
• UniProt Entry Name: FANCC_HUMAN

Uniprot Description

FANCC: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. Defects in FANCC are the cause of Fanconi anemia complementation group C (FANCC). A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.

Chromosomal Location of Human Ortholog: 9q22.3

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol

Molecular Function: protein binding

Biological Process: removal of superoxide radicals; nucleotide-excision repair; myeloid cell homeostasis; protein complex assembly; DNA repair; germ cell development

Disease: Fanconi Anemia, Complementation Group C; Tracheoesophageal Fistula With Or Without Esophageal Atresia