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Rabbit FAM62B Polyclonal Antibody | anti-ESYT2 antibody

FAM62B Antibody

Gene Names
ESYT2; E-Syt2; FAM62B; CHR2SYT
Reactivity
Human, Mouse, Rat
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
FAM62B; Polyclonal Antibody; FAM62B Antibody; Chr2 synaptotagmin; CHR2SYT; E Syt2; ESYT 2; ESYT2; Extended synaptotagmin 2; Extended synaptotagmin like protein 2; FAM 62B; Family with sequence similarity 62 (C2 domain containing) member B; Family with sequence similarity 62 member B; KIAA1228; Protein FAM62B; anti-ESYT2 antibody
Ordering
 
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For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
FAM62B Antibody detects endogenous levels of total FAM62B.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-ESYT2 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from Human MYOCD.
Conjugation
Unconjugated
Similarity
Anchored to the endoplasmic reticulum membrane by a transmembrane hairpin structure; both N-terminus and C-terminus are cytoplasmic. The C2 domains mediate lipid and calcium binding. The N-terminal C2 domain binds calcium ions and is important for calcium-dependent lipid binding and interaction with membranes. Two calcium ions are bound at a high-affinity site and a third calcium ion is bound with lower affinity. May bind up to four calcium ions. In contrast, the second C2 domain apparently does not bind calcium (PubMed:24373768). The third C2 domain mediates interaction with membranes enriched in phosphatidylinositol 4, 5-bisphosphate and is required for location at the cell membrane (PubMed:23791178). The SMP-LTD domain is a barrel-like domain that binds glycerophospholipids in its interior; can bind two lipid molecules simultaneously. Binds a variety of lipids, including phosphatidylethanolamine, phosphatidylcholine and phosphatidylinositol (PubMed:24847877). Belongs to the extended synaptotagmin family.
Subunit Structure
Homodimer. Interacts with ESYT1 and ESYT3. Interacts with FGFR1 that has been activated by FGF1 binding. Interacts with the AP-2 complex; identified in a complex with the AP-2 complex and FGFR1.
Tissue Specificity
Widely expressed with high level in cerebellum.
Function
Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex.
Note
Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:29469807, PubMed:23791178, PubMed:30220461). Recruited to the cell membrane via the third C2 domain (PubMed:17360437).
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
104,708 Da
NCBI Official Full Name
extended synaptotagmin-2
NCBI Official Synonym Full Names
extended synaptotagmin-like protein 2
NCBI Official Symbol
ESYT2
NCBI Official Synonym Symbols
E-Syt2; FAM62B; CHR2SYT
NCBI Protein Information
extended synaptotagmin-2; chr2 synaptotagmin; family with sequence similarity 62 (C2 domain containing), member B
UniProt Protein Name
Extended synaptotagmin-2
Protein Family
UniProt Gene Name
ESYT2
UniProt Synonym Gene Names
FAM62B; KIAA1228; E-Syt2
UniProt Entry Name
ESYT2_HUMAN

Uniprot Description

ESYT2: May play a role as calcium-regulated intrinsic membrane protein. Belongs to the extended synaptotagmin family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 7q36.3

Cellular Component: intrinsic to endoplasmic reticulum membrane; extrinsic to internal side of plasma membrane; membrane; integral to plasma membrane

Molecular Function: identical protein binding; protein binding; phosphatidylethanolamine binding; calcium-dependent phospholipid binding; phosphatidylcholine binding; calcium ion binding; phosphoinositide binding

Biological Process: endocytosis; lipid transport

Research Articles on ESYT2

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Product Notes

The ESYT2 esyt2 (Catalog #AAA9629454) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FAM62B Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's FAM62B can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the ESYT2 esyt2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FAM62B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.
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