Rabbit FAM129B Polyclonal Antibody | anti-FAM129B antibody
FAM129B Antibody
Gene Names
FAM129B; OC58; MEG-3; C9orf88; MINERVA; bA356B19.6
Reactivity
Human, Mouse, Rat
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
FAM129B; Polyclonal Antibody; FAM129B Antibody; bA356B19.6; C9orf88; chromosome 9 open reading frame 88; DKFZP434H0820; family with sequence similarity 129; member B; FLJ13518; FLJ22151; FLJ22298; hypothetical protein LOC64855; Meg 3; Meg-3; Meg3; Niban like protein 1; Niban-like protein 1; NIBL1_HUMAN; OC58; OTTHUMP00000022187; OTTHUMP00000022188; Protein FAM129B; anti-FAM129B antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
FAM129B Antibody detects endogenous levels of FAM129B.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-FAM129B antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human FAM129B.
Conjugation
Unconjugated
Similarity
Belongs to the Niban family.
Post Translational Modifications
Phosphorylated at Ser-641, Ser-646, Ser-692 and Ser-696 by the BRAF/MKK/ERK signaling cascade. In melanoma cells, the C-terminal phosphorylation may prevent targeting to the plasma membrane.As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases.
Function
May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro.
Note
In exponentially growing cells, exclusively cytoplasmic. Cell membrane localization is observed when cells reach confluency and during telophase. In melanoma cells, targeting to the plasma membrane may be impaired by C-terminal phosphorylation.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-FAM129B antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
~83 kDa
NCBI Official Full Name
niban-like protein 1 isoform 2
NCBI Official Synonym Full Names
family with sequence similarity 129 member B
NCBI Official Symbol
FAM129B
NCBI Official Synonym Symbols
OC58; MEG-3; C9orf88; MINERVA; bA356B19.6
NCBI Protein Information
niban-like protein 1
UniProt Protein Name
Niban-like protein 1
Protein Family
UniProt Gene Name
FAM129B
UniProt Synonym Gene Names
C9orf88; MINERVA
UniProt Entry Name
NIBL1_HUMAN
Uniprot Description
FAM129B: a maternal imprinting gene. Absent in pituitary adenomas. May possess growth suppressor activity. Two major alternatively spliced isoforms have been described. forms. One form, Meg3-proximal ( Meg3p), contains exons 1-3. The second form, Meg3-distal ( Meg3d) did not contain exons 1-3 and was present in oocytes and in 1- and 2-cell embryos.
Protein type: Cell adhesion
Chromosomal Location of Human Ortholog: 9q34.13
Cellular Component: actin cytoskeleton; adherens junction; cytoplasm; cytosol; nucleolus; nucleoplasm; nucleus; plasma membrane
Biological Process: negative regulation of apoptosis
Research Articles on FAM129B
Similar Products
Product Notes
The FAM129B fam129b (Catalog #AAA9629964) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FAM129B Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's FAM129B can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the FAM129B fam129b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FAM129B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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