Rabbit FAIM3 Polyclonal Antibody | anti-FAIM3 antibody

FAIM3 Antibody

Cat. Num. AAA9608540

• Gene Names: FCMR; TOSO; FAIM3
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Synonyms: FAIM3; Polyclonal Antibody; FAIM3 Antibody; Faim3; FAIM3_HUMAN; Fas apoptotic inhibitory molecule 3; Fc fragment of IgM receptor; Fc mu receptor; FCMR; IgM Fc receptor; Immunoglobulin mu Fc receptor; Regulator of Fas induced apoptosis; Regulator of Fas-induced apoptosis Toso; TOSO; anti-FAIM3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: FAIM3 antibody detects endogenous levels of total FAIM3
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Form/Format: Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 278

• Applicable Applications for anti-FAIM3 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:1000-3000
• Immunogen: A synthesized peptide derived from human FAIM3
• Subcellular Location: Membrane.
• Tissue Specificity: Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11; 19 and Reh. No expression detected in nonhematopoietic cell lines including Hep-G2, HEK293 and HeLa. Detected at high levels in chronic lymphocytic leukemia cells.
• Predicted Cross Reactivity: Pig, Bovine, Sheep, Dog
• Similarity: Pig (83%), Bovine (80%), Sheep (80%), Dog (80%)
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot analysis FAIM3 using Jurkat whole cell lysates)

Related Product Information for anti-FAIM3 antibody

Function: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha-and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
Similarity: The Ig-like domain is required for the anti-apoptotic ability.

NCBI and Uniprot Product Information

• NCBI GI #: 216547554
• NCBI GeneID: 9214
• NCBI Accession #: NP_001135945.1
• NCBI GenBank Nucleotide #: NM_001142473.1
• UniProt Accession #: O60667; A8K7J2; B7Z6Z0; D9MWM3
• Molecular Weight: Observed: 43 kDa; Predicted: 44 kDa
• NCBI Official Full Name: fas apoptotic inhibitory molecule 3 isoform b
• NCBI Official Synonym Full Names: Fc fragment of IgM receptor
• NCBI Official Symbol: FCMR
• NCBI Official Synonym Symbols: TOSO; FAIM3
• NCBI Protein Information: fas apoptotic inhibitory molecule 3
• UniProt Protein Name: Fas apoptotic inhibitory molecule 3
• UniProt Gene Name: FCMR
• UniProt Synonym Gene Names: FAIM3; TOSO

NCBI Description

Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]

Uniprot Description

May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.