Rabbit anti-Human Factor VIII Polyclonal Antibody | anti-F8 antibody

Factor VIII Antibody BIOTIN-Conjugated

Cat. Num. AAA541644

• Gene Names: F8; AHF; F8B; F8C; HEMA; FVIII; DXS1253E
• Reactivity: Human
• Applications: ELISA, Immunoprecipitation, Western Blot
• Synonyms: Factor VIII; Polyclonal Antibody; Factor VIII Antibody BIOTIN-Conjugated; AHF; Antihemophilic factor; Coagulation factor VIII; coagulation factor VIII; procoagulant component; DXS1253E; F8; F8b; F8c; factor VIII F8B; Factor VIIIa light chain; FactorVIII; FVIII; Hema; Hemophilia A antibodyProcoagulant component antibody; anti-F8 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Form/Format: BIOTIN-Conjugated
• Concentration: 0.75-0.95 ug/ul in antibody stabilization buffer (varies by lot)
• Sequence Length: 329

• Applicable Applications for anti-F8 antibody: ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: ELISA: 1:10,000; Immunoprecipitation: 1:200; Western Blot: 1:500
• Immunogen: Synthetic peptide taken within amino acid region 200-250 on human Coagulation Factor VIII protein.
• Immunoglobulin: IgG
• Molecular Function: Copper ion binding; oxidoreductase activity
• Structure: Interacts with vWF. vWF binding is essential for the stabilization of F8 in circulation.
• Subcellular Location: Secreted ; Extracellular space
• Preparation and Storage: -20 degree C for long term storage

Related Product Information for anti-F8 antibody

BIOTIN-Conjugated coagulation factor VIII Antibody
Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.

NCBI and Uniprot Product Information

• NCBI GI #: 295007368
• NCBI GeneID: 2157
• UniProt Accession #: D5H408; P00451
• Molecular Weight: 37,109 Da
• NCBI Official Full Name: factor VIII, partial
• NCBI Official Synonym Full Names: coagulation factor VIII
• NCBI Official Symbol: F8
• NCBI Official Synonym Symbols: AHF; F8B; F8C; HEMA; FVIII; DXS1253E
• NCBI Protein Information: coagulation factor VIII
• UniProt Protein Name: Factor VIII
• Protein Family: Factor VIII intron 22 protein
• UniProt Gene Name: F8
• UniProt Entry Name: D5H408_HUMAN

NCBI Description

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]