Rabbit FABP2 Polyclonal Antibody | anti-FABP2 antibody

FABP2 Polyclonal Antibody

Cat. Num. AAA3008071

• Gene Names: FABP2; FABPI; I-FABP
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: FABP2; Polyclonal Antibody; FABP2 Polyclonal Antibody; FABP 2; FABPI; Fatty acid binding protein 2 intestinal; Fatty acid binding protein; Fatty acid binding protein intestinal; Fatty acid-binding protein 2; Fatty acid-binding protein; I FABP; I-FABP; IFABP; intestinal; Intestinal fatty acid binding protein 2; Intestinal-type fatty acid-binding protein; MGC133132; OTTHUMP00000163925; anti-FABP2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: FABP2 polyclonal antibody detects endogenous levels of FABP2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 132

• Applicable Applications for anti-FABP2 antibody: Western Blot (WB), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IF: 1:10-1:100
• Immunogen: Recombinant full length Human FABP2.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of extracts of 293T cell lines, using FABP2 antibody.)

Related Product Information for anti-FABP2 antibody

-Fatty acid-binding proteins, designated FABPs, are a family of homologous cytoplasmic proteins that are expressed in a highly tissue-specific manner and play an integral role in the balance between lipid and carbohydrate metabolism. FABPs mediate fatty acid (FA) and/or hydrophobic ligand uptake, transport and targeting within their respective tissues. The mechanisms underlying these actions can give rise to both passive diffusional uptake and protein-mediated transmembrane transport of FAs. FABPs are expressed in adipocytes (A-FABP), brain (B-FABP), epidermis (E-FABP, also designated psoriasis-associated FABP or PA-FABP), muscle and heart (H-FABP, also designated mammary-derived growth inhibitor or MDGI), intestine (I-FABP), liver (L-FABP), myelin (M-FABP) and testis (T-FABP). Intestinal FABP (I-FABP) is an abundant cytosolic protein abundant in small intestine epithelial cells. The human gene maps to chromosome 4q26 and has a polymorphism at codon 54, which confers an alanine-encoding allele and a threonine-encoding allele. Threonine at position 54 is associated with increased fat oxidation and Insulin resistance.

NCBI and Uniprot Product Information

• NCBI GI #: 119805
• NCBI GeneID: 2169
• UniProt Accession #: P12104
• Molecular Weight: ~15kDa
• NCBI Official Full Name: Fatty acid-binding protein, intestinal
• NCBI Official Synonym Full Names: fatty acid binding protein 2
• NCBI Official Symbol: FABP2
• NCBI Official Synonym Symbols: FABPI; I-FABP
• NCBI Protein Information: fatty acid-binding protein, intestinal
• UniProt Protein Name: Fatty acid-binding protein, intestinal
• Protein Family: Fatty acid-binding protein
• UniProt Gene Name: FABP2
• UniProt Synonym Gene Names: FABPI; I-FABP
• UniProt Entry Name: FABPI_HUMAN

NCBI Description

The protein encoded by this gene is an intracellular fatty acid-binding protein that participates in the uptake, intracellular metabolism, and transport of long-chain fatty acids. The encoded protein is also involved in the modulation of cell growth and proliferation. This protein binds saturated long-chain fatty acids with high affinity, and may act as a lipid sensor to maintain energy homeostasis. [provided by RefSeq, Aug 2017]

Uniprot Description

FABP2: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long- chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Chromosomal Location of Human Ortholog: 4q28-q31

Cellular Component: cytoplasm

Molecular Function: transporter activity; fatty acid binding

Biological Process: transport; digestion