Western Blot (WB)
(Western blot analysis of F1A alpha in mouse (A) and rat (B) liver tissue lysates with F1A alpha antibody at 1 ug/mL.)
Rabbit F1A alpha Polyclonal Antibody | anti-F1A alpha antibody
F1A alpha Antibody
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
Affinity chromatography purified via peptide column
Synonyms
F1A alpha; Polyclonal Antibody; F1A alpha Antibody; anti-F1A alpha antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
627
Applicable Applications for anti-F1A alpha antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Immunogen Type
Peptide
Immunogen Description
Raised against a peptide corresponding to amino acids 609 to 622 of human F1A alpha. This sequence is identical to the corresponding sequence of mouse FEM1b.
Target Name
F1A alpha
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of F1A alpha in mouse (A) and rat (B) liver tissue lysates with F1A alpha antibody at 1 ug/mL.)
Western Blot (WB)
(Western blot analysis of F1A alpha in mouse (A) and rat (B) liver tissue lysates with F1A alpha antibody at 1 ug/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of F1Aa in mouse liver tissue with F1Aa antibody at 5 ug/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of F1Aa in mouse liver tissue with F1Aa antibody at 5 ug/mL.)
Related Product Information for anti-F1A alpha antibody
Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aalpha and FEM1b. F1Aalpha/FEM1b is the homologue of C. elegans sex determining protein FEM-1. FEM-1/F1Aalpha is cleaved by CED-3 and caspase. FEM-1/F1Aalpha associates with CED-4 and its mammalian homologue Apaf-1. Overexpression of F1Aalpha induces apoptosis. F1Aalpha is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aalpha is expressed in a variety of human and mouse tissues.
Product Categories/Family for anti-F1A alpha antibody
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
70,264 Da
NCBI Official Full Name
FEM-1-like death receptor binding protein
UniProt Protein Name
Protein fem-1 homolog B
UniProt Gene Name
FEM1B
UniProt Synonym Gene Names
F1AA; KIAA0396; FEM1b; F1A-alpha
UniProt Entry Name
FEM1B_HUMAN
Uniprot Description
FEM1B: Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1. Belongs to the fem-1 family.
Protein type: Ubiquitin conjugating system; Cell development/differentiation; Apoptosis; Ligase
Chromosomal Location of Human Ortholog: 15q22
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: protein binding; death receptor binding; ubiquitin-protein ligase activity
Biological Process: apoptosis; regulation of ubiquitin-protein ligase activity; protein ubiquitination
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Product Notes
The F1A alpha fem1b (Catalog #AAA9412594) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The F1A alpha Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's F1A alpha can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the F1A alpha fem1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "F1A alpha, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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