Western Blot (WB)
(EXOSC6 Antibody (N-term) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the EXOSC6 antibody detected the EXOSC6 protein (arrow).)
Rabbit anti-Human EXOSC6 Polyclonal Antibody | anti-EXOSC6 antibody
EXOSC6 Antibody (N-term)
Western Blot (WB)
(EXOSC6 Antibody (N-term) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the EXOSC6 antibody detected the EXOSC6 protein (arrow).)
Western Blot (WB)
(EXOSC6 Antibody (N-term) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the EXOSC6 antibody detected the EXOSC6 protein (arrow).)
multisubunit particle called exosome, which mediates mRNA
degradation. The composition of human exosome is similar to its
yeast counterpart. This protein is homologous to the yeast Mtr3
protein. Its exact function is not known, however, it has been
shown using a cell-free RNA decay system that the exosome is
required for rapid degradation of unstable mRNAs containing AU-rich
elements (AREs), but not for poly(A) shortening. The exosome does
not recognize ARE-containing mRNAs on its own, but requires
ARE-binding proteins that could interact with the exosome and
recruit it to unstable mRNAs, thereby promoting their rapid
degradation.
Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)
Raijmakers, R., et al. J. Mol. Biol. 323(4):653-663(2002)
van Hoof, A., et al. Curr. Biol. 12 (8), R285-R287 (2002) :
Raijmakers, R., et al. J. Mol. Biol. 315(4):809-818(2002)
NCBI and Uniprot Product Information
NCBI Description
This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. [provided by RefSeq, Jul 2008]
Uniprot Description
EXOSC6: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. Belongs to the RNase PH family.
Protein type: Ribonuclease; EC 3.1.13.-; Nucleolus
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: nucleolus; exosome (RNase complex); cytosol
Molecular Function: exoribonuclease activity
Biological Process: isotype switching; gene expression; DNA deamination; rRNA processing; mRNA catabolic process, deadenylation-dependent decay
Research Articles on EXOSC6
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Product Notes
The EXOSC6 exosc6 (Catalog #AAA9201834) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 12-38. The EXOSC6 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's EXOSC6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the EXOSC6 exosc6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "EXOSC6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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