Western Blot (WB)
(Western Blot analysis of HEPG2 3T3 Hela cells using ERLIN1/2 Polyclonal Antibody diluted at 1:800. Secondary antibody was diluted at 1:20000)
Rabbit ERLIN1/2 Polyclonal Antibody | anti-ERLIN1/2 antibody
ERLIN1/2 Polyclonal Antibody
IHC: 1:100-1:300
Western Blot (WB)
(Western Blot analysis of HEPG2 3T3 Hela cells using ERLIN1/2 Polyclonal Antibody diluted at 1:800. Secondary antibody was diluted at 1:20000)
Western Blot (WB)
(Western Blot analysis of HEPG2 3T3 Hela cells using ERLIN1/2 Polyclonal Antibody diluted at 1:800. Secondary antibody was diluted at 1:20000)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is part of a protein complex that mediates degradation of inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum. The encoded protein also binds cholesterol and regulates the SREBP signaling pathway, which promotes cellular cholesterol homeostasis. Defects in this gene have been associated with spastic paraplegia 62. [provided by RefSeq, Dec 2016]
Uniprot Description
SPFH1: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Belongs to the band 7/mec-2 family. Forms a heteromeric complex with ERLIN2.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 10q24.31
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; protein complex
Molecular Function: cholesterol binding; protein binding
Biological Process: ER-associated protein catabolic process; negative regulation of cholesterol biosynthetic process; negative regulation of fatty acid biosynthetic process; SREBP-mediated signaling pathway; transmembrane transport
Disease: Spastic Paraplegia 62, Autosomal Recessive
Research Articles on ERLIN1/2
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Product Notes
The ERLIN1/2 erlin1 (Catalog #AAA9419723) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ERLIN1/2 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ERLIN1/2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500-1:2000 IHC: 1:100-1:300. Researchers should empirically determine the suitability of the ERLIN1/2 erlin1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ERLIN1/2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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