Rabbit anti-Mouse Ephrin A2/EFNA2 Polyclonal Antibody | anti-EFNA2 antibody
Anti-Ephrin A2/EFNA2 Antibody, Rabbit Polyclonal
Gene Names
Efna2; Elf1; Epl6; CEK7L; Eplg6; Lerk6
Reactivity
Mouse
Applications
ELISA
Purity
Protein A & Antigen Affinity
Synonyms
Ephrin A2/EFNA2; Polyclonal Antibody; Anti-Ephrin A2/EFNA2 Antibody; Rabbit Polyclonal; Ephrin-A2/EFNA2 Antibody; Rabbit PAb; Antigen Affinity Purified; ephrin-A2; Anti-CEK7L Antibody; Anti-Elf1 Antibody; Anti-Epl6 Antibody; Anti-Eplg6 Antibody; Anti-Lerk6 Antibody; anti-EFNA2 antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Mouse Ephrin-A2/EFNA2
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-EFNA2 antibody
ELISA (EIA)
Application Notes
ELISA: 1:5000-1:10,000
Immunogen
Recombinant Mouse Ephrin-A2/EFNA2 protein
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with purified, recombinant Mouse Ephrin-A2/EFNA2 (rM Ephrin-A2/EFNA2). Ephrin-A2/EFNA2 specific IgG was purified by Mouse Ephrin-A2/EFNA2 affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-EFNA2 antibody
Ephrin-A2 also known as EFNA2 or EPH-related receptor tyrosine kinase ligand 6, is a member of the ephrin family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin-A2 and their Eph family of receptor tyrosine kinases are expressed by cells of the SVZ. Eph/ephrin interactions are implicated in axon guidance, neural crest cell migration, establishment of segmental boundaries, and formation of angiogenic capillary plexi. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. Ephrin-A2 regulates the position-specific affinity of limb mesenchyme and is involved in cartilage pattern formation in the limb.
References
Feldheim DA, et al. (2000) Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping. Neuron. 25(3): 563-74.Jurney WM, et al. (2002) Rac1-mediated endocytosis during ephrin-A2-and semaphorin 3A-induced growth cone collapse. J Neurosci. 22(14): 6019-28.Holmberg J, et al. (2005) Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis. Genes Dev. 19(4): 462-71.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
23,586 Da
NCBI Official Full Name
ephrin-A2
NCBI Official Synonym Full Names
ephrin A2
NCBI Official Symbol
Efna2
NCBI Official Synonym Symbols
Elf1; Epl6; CEK7L; Eplg6; Lerk6
NCBI Protein Information
ephrin-A2
UniProt Protein Name
Ephrin-A2
Protein Family
UniProt Gene Name
Efna2
UniProt Synonym Gene Names
Elf1; Epl6; Eplg6; Lerk6; CEK7-L; LERK-6
UniProt Entry Name
EFNA2_MOUSE
Uniprot Description
EFNA2: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. Belongs to the ephrin family.
Protein type: Ligand, receptor tyrosine kinase; Membrane protein, GPI anchor
Cellular Component: membrane; neuromuscular junction; perikaryon; plasma membrane
Molecular Function: ephrin receptor binding; protein binding
Biological Process: axon guidance; bone remodeling; ephrin receptor signaling pathway; osteoclast differentiation
Research Articles on EFNA2
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Product Notes
The EFNA2 efna2 (Catalog #AAA8111775) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Ephrin A2/EFNA2 Antibody, Rabbit Polyclonal reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Ephrin A2/EFNA2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). ELISA: 1:5000-1:10,000. Researchers should empirically determine the suitability of the EFNA2 efna2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Ephrin A2/EFNA2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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