Mouse Ephrin-A2 ELISA Kit | Efna2 elisa kit
Mouse Ephrin-A2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
EFNA2: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. Belongs to the ephrin family.
Protein type: Ligand, receptor tyrosine kinase; Membrane protein, GPI anchor
Cellular Component: membrane; neuromuscular junction; perikaryon; plasma membrane
Molecular Function: ephrin receptor binding; protein binding
Biological Process: axon guidance; bone remodeling; ephrin receptor signaling pathway; osteoclast differentiation