Rabbit anti-Human EphA3 Receptor Polyclonal Antibody | anti-Epha3 antibody

EphA3 Receptor (Ephrin A3 Receptor)

Cat. Num. AAA611018

• Gene Names: Epha3; Hek; Cek4; ETK1; End3; Hek4; Mek4; Tyro4; AW492086
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified; Purified by epitope affinity chromatography.
• Synonyms: EphA3 Receptor; Polyclonal Antibody; EphA3 Receptor (Ephrin A3 Receptor); Anti -EphA3 Receptor (Ephrin A3 Receptor); anti-Epha3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Reacts with the ~110kD (calculated molecular weight) human EphA3 receptor.
• Purity/Purification: Purified; Purified by epitope affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.

• Applicable Applications for anti-Epha3 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot: 1-3ug/ml
• Immunogen: Synthetic peptide derived from the C-terminal region of the human EphA3 receptor protein.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-Epha3 antibody

Eph receptors belong to a family of receptor tyrosine kinases. Both ephrins, the ligands for Eph receptors, and Eph receptors are broadly expressed throughout the ectoderm, mesoderm, and endoderm of vertebrate embryos. The interaction of ephrins with the appropriate Eph receptors has been implicated in a wide spectrum of functions in vertebrate morphogenesis, including the accurate migration of embryonic cells, formation of boundaries between structures (i.e. rhombomeres and somites), and the control of cytoskeletal changes which dictate cellular shape and adhesion during development. EphA3 receptor, also known as Cek4, Mek4, Hek, Tyro4 and Hek4, is thought to repel receptor positive myoblasts and axons away from the limb bud and towards the body wall. EphA3 receptor is involved in targeting of the retinotectal projection and the organization of the retinotectal pathway.

Product Categories/Family for anti-Epha3 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 31982448
• NCBI GeneID: 13837
• NCBI Accession #: NP_034270.1
• NCBI GenBank Nucleotide #: NM_010140.3
• UniProt Accession #: P29319
• Molecular Weight: 109,955 Da
• NCBI Official Full Name: ephrin type-A receptor 3
• NCBI Official Synonym Full Names: Eph receptor A3
• NCBI Official Symbol: Epha3
• NCBI Official Synonym Symbols: Hek; Cek4; ETK1; End3; Hek4; Mek4; Tyro4; AW492086
• NCBI Protein Information: ephrin type-A receptor 3; EK4; EPH-like kinase 4; tyrosine-protein kinase TYRO4; tyrosine-protein kinase receptor ETK1
• UniProt Protein Name: Ephrin type-A receptor 3
• Protein Family: Ephrin type-A receptor
• UniProt Gene Name: Epha3
• UniProt Synonym Gene Names: Etk1; Mek4; Tyro4; EK4; mEK4
• UniProt Entry Name: EPHA3_MOUSE

Uniprot Description

EphA3: a receptor tyrosine kinase of the Eph family. Receptor for members of the ephrin-A family: binds to ephrin-A2, -A3, -A4 and -A5The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. Two point mutations seen in a survey of colorectal tumors. Soluble receptors reduce tumor growth and angiogenesis in mouse models. Two alternatively spliced isoforms of EphA3 have been described.

Protein type: Protein kinase, TK; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Kinase, protein; Membrane protein, integral; TK group; Eph family

Cellular Component: membrane; integral to plasma membrane; early endosome; integral to membrane; plasma membrane; extracellular region

Molecular Function: transferase activity; GPI-linked ephrin receptor activity; protein-tyrosine kinase activity; ephrin receptor activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding; protein kinase activity

Biological Process: cell migration; peptidyl-tyrosine phosphorylation; regulation of actin cytoskeleton organization and biogenesis; regulation of focal adhesion formation; ephrin receptor signaling pathway; motor axon guidance; protein amino acid phosphorylation; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway