Mouse Sortilin-Related Receptor (SORL1) ELISA Kit | SORL1 elisa kit

Mouse Sortilin-Related Receptor (SORL1) ELISA Kit

Cat. Num. AAA9717011

• Gene Names: Sorl1; LR11; SorLA; gp250; mSorLA; AI596264; AW261561; 2900010L19Rik
• Reactivity: Mouse
• Synonyms: Sortilin-Related Receptor (SORL1); Mouse Sortilin-Related Receptor (SORL1) ELISA Kit; SORL1; C11orf32; FLJ21930; FLJ39258; LR11; LRP9; SORLA; SorLA-1; gp250; mosaic protein LR11; sortilin-related receptor containing LDLR class A repeats; SORL1 elisa kit

• Reactivity: Mouse
• Specificity: Mouse Sortilin-related receptor (SORL1) ELISA Kit has high sensitivity and excellent specificity for detection of Mouse SORL1. No significant cross-reactivity or interference between Mouse SORL1 and analogues was observed.
• Sequence Length: 2215

• Assay Type: Sandwich
• Preparation and Storage: Store at 2-8 degree C.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for SORL1 elisa kit

Principle of the Assay: Mouse Sortilin-related Receptor (SORL1) ELISA Kit employs a two-site sandwich ELISA to quantitate SORL1 in samples. An antibody specific for SORL1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any SORL1 present is bound by the immobilized antibody. After removing any unbound substances, HRP-Conjugated Mouse SORL1 detection antibody is added to the wells. Following a wash to remove any unbound HRP reagent, a Chromogen solution is added to the wells and color develops in proportion to the amount of SORL1 bound in the initial step. The color development is stopped and the intensity of the color is measured.!!Background/Introduction: SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar SORL1 encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain protein sorting 10 (VPS10) domain -containing receptor family containing receptor family containing receptor family containing receptor family containing receptor family containing receptor family containing receptor family containing receptor family containing receptor family containing receptor family containing receptor family containing receptor family containing receptor family containing receptor family containing receptor family containing receptor family 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The encoded preproprotein is repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting. Mutations in SORL1 may be associated with Alzheimer's disease.

NCBI and Uniprot Product Information

• NCBI GI #: 110625645
• NCBI GeneID: 20660
• NCBI Accession #: NP_035566.2
• NCBI GenBank Nucleotide #: NP_035566.2
• UniProt Accession #: O88307
• NCBI Official Full Name: sortilin-related receptor isoform 1
• NCBI Official Synonym Full Names: sortilin-related receptor, LDLR class A repeats-containing
• NCBI Official Symbol: Sorl1
• NCBI Official Synonym Symbols: LR11; SorLA; gp250; mSorLA; AI596264; AW261561; 2900010L19Rik
• NCBI Protein Information: sortilin-related receptor
• UniProt Protein Name: Sortilin-related receptor
• Protein Family: Sortilin-related receptor
• UniProt Gene Name: Sorl1
• UniProt Synonym Gene Names: LDLR relative with 11 ligand-binding repeats; LR11; mSorLA

Uniprot Description

SORL1: Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction. Belongs to the VPS10-related sortilin family. SORL1 subfamily.

Protein type: Cell surface; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 9|9 A5.1

Cellular Component: cell soma; early endosome; endoplasmic reticulum; endosome; extracellular region; extracellular space; Golgi apparatus; Golgi cisterna; integral component of membrane; membrane; multivesicular body; nuclear envelope lumen; perinuclear region of cytoplasm; recycling endosome; trans-Golgi network

Molecular Function: ADP-ribosylation factor binding; amyloid-beta binding; low-density lipoprotein particle binding; protein binding

Biological Process: cell migration; cholesterol metabolic process; endocytosis; lipid metabolic process; lipid transport; multicellular organism development; negative regulation of MAP kinase activity; negative regulation of neurogenesis; negative regulation of protein binding; negative regulation of protein oligomerization; positive regulation of protein catabolic process; post-Golgi vesicle-mediated transport; protein maturation; protein retention in Golgi apparatus; protein targeting; protein targeting to Golgi; protein targeting to lysosome; regulation of smooth muscle cell migration; steroid metabolic process; transport