Rabbit anti-Human, Mouse ELOVL6 Polyclonal Antibody | anti-ELOVL6 antibody

ELOVL6 Rabbit pAb

Cat. Num. AAA4760697

• Gene Names: ELOVL6; FAE; LCE; FACE
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: ELOVL6; Polyclonal Antibody; ELOVL6 Rabbit pAb; ELOVL fatty acid elongase 6; FAE; LCE; FACE; anti-ELOVL6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purified
• Form/Format: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: 0.6mg/ml (varies by lot)

• Applicable Applications for anti-ELOVL6 antibody: Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: WB: 1:500-1:2000; IHC-P: 1:20-1:100
• Immunogen: Synthetic peptide of human ELOVL6
• Conjugation: Unconjugated
• Modification: Unmodified
• Preparation and Storage: Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.

Western Blot (WB)

(Western Blot analysis of ELOVL6 in Mouse brain tissue lysate using ELOVL6 Rabbit pAb at dilution 1/500)

Immunohistochemistry (IHC)

(Immunohistochemistry of ELOVL6 in paraffin-embedded Human tonsil tissue using ELOVL6 Rabbit pAb at dilution 1/20. Predicted cell location: Cytoplasm)

Related Product Information for anti-ELOVL6 antibody

Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

NCBI and Uniprot Product Information

• NCBI GI #: 195539343
• NCBI GeneID: 79071
• NCBI Accession #: NP_001124193.1
• NCBI GenBank Nucleotide #: NM_001130721.1
• UniProt Accession #: Q9H5J4; Q4W5L0; Q8NCD1
• Molecular Weight: 31,376 Da
• NCBI Official Full Name: elongation of very long chain fatty acids protein 6
• NCBI Official Synonym Full Names: ELOVL fatty acid elongase 6
• NCBI Official Symbol: ELOVL6
• NCBI Official Synonym Symbols: FAE; LCE; FACE
• NCBI Protein Information: elongation of very long chain fatty acids protein 6; hELO2; ELOVL FA elongase 6; fatty acid elongase 2; fatty acyl-CoA elongase; long-chain fatty-acyl elongase; 3-keto acyl-CoA synthase ELOVL6; very-long-chain 3-oxoacyl-CoA synthase 6; ELOVL family member
• UniProt Protein Name: Elongation of very long chain fatty acids protein 6
• UniProt Gene Name: ELOVL6
• UniProt Synonym Gene Names: FACE; LCE; ELOVL FA elongase 6; hELO2
• UniProt Entry Name: ELOV6_HUMAN

NCBI Description

Fatty acid elongases (EC 6.2.1.3), such as ELOVL6, use malonyl-CoA as a 2-carbon donor in the first and rate-limiting step of fatty acid elongation (Moon et al., 2001 [PubMed 11567032]).[supplied by OMIM, Mar 2008]

Uniprot Description

ELOVL6: Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16:0 acyl-CoAs. Belongs to the ELO family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; EC 2.3.1.199

Chromosomal Location of Human Ortholog: 4q25

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to endoplasmic reticulum membrane

Molecular Function: protein binding; transferase activity, transferring groups other than amino-acyl groups

Biological Process: long-chain fatty acid biosynthetic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; fatty acid elongation, saturated fatty acid