Rabbit anti-Human ELF3 Polyclonal Antibody | anti-ELF3 antibody

ELF3 (E74-like Factor 3, ets Domain Transcription Factor, Epithelial-specific, DKFZP686F2495, EPR-1, ERT, ESE-1, ESX)

Cat. Num. AAA618047

• Gene Names: ELF3; ERT; ESX; EPR-1; ESE-1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified; Purified
• Synonyms: ELF3; Polyclonal Antibody; ELF3 (E74-like Factor 3; ets Domain Transcription Factor; Epithelial-specific; DKFZP686F2495; EPR-1; ERT; ESE-1; ESX); Anti -ELF3 (E74-like Factor 3; anti-ELF3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: This antibody recognizes both isoforms of ESE-1. Species Crossreactivity: Human. Others species have not been tested.
• Purity/Purification: Purified; Purified
• Form/Format: Supplied as a liquid in PBS with 0.02% sodium azide

• Applicable Applications for anti-ELF3 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot: 1:500 (ECL detection)
• Immunogen: N-terminal sequence and C-terminal sequence of the human ESE-1 protein.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-ELF3 antibody

ESE-1 (Epithelium-Specific Ets) is a novel, highly tissue-restricted member of the ets transcription factor/oncogene family, which has features distinct from those of any other ets-related factor. ESE-1 binds with high affinity to and transactivates the ets binding site in the promoter of the keratinocyte terminal differentiation marker gene, SPRR2A. ESE-1 is a critical regulator of epithelial cell differentiation.

Product Categories/Family for anti-ELF3 antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 167235023
• NCBI GeneID: 1999
• NCBI Accession #: NP_004424.3
• NCBI GenBank Nucleotide #: NM_004433.4
• UniProt Accession #: P78545; Q6IAP8; Q7RU03; Q7Z3X2; Q8NFG2; Q99718; B2R5Q6; Q5SR36
• Molecular Weight: 41,454 Da
• NCBI Official Full Name: ETS-related transcription factor Elf-3
• NCBI Official Synonym Full Names: E74-like factor 3 (ets domain transcription factor, epithelial-specific )
• NCBI Official Symbol: ELF3
• NCBI Official Synonym Symbols: ERT; ESX; EPR-1; ESE-1
• NCBI Protein Information: ETS-related transcription factor Elf-3; OTTHUMP00000034050; OTTHUMP00000034051; OTTHUMP00000034052; OTTHUMP00000034053; epithelial-restricted with serine box; epithelium-restricted Ets protein ESX; epithelium-specific Ets transcription factor 1; E74-like factor 3 (ets domain transcription factor); ets domain transcription factor, serine box (epithelial-specific); E74-like factor 3 (ETS domain transcription factor, serine box, epithelial-specific)
• UniProt Protein Name: ETS-related transcription factor Elf-3
• Protein Family: ELF3-like protein
• UniProt Gene Name: ELF3
• UniProt Synonym Gene Names: ERT; ESX; JEN
• UniProt Entry Name: ELF3_HUMAN

Uniprot Description

ELF3: Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development. Belongs to the ETS family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q32.2

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; transcription coactivator activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; mammary gland involution; epidermis development; blastocyst development; extracellular matrix organization and biogenesis; epithelial cell differentiation; multicellular organismal development; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; negative regulation of transcription, DNA-dependent