Rabbit anti-Human, Mouse EID1 Polyclonal Antibody | anti-EID1 antibody

EID1 Antibody

Cat. Num. AAA9409377

• Gene Names: EID1; CRI1; EID-1; RBP21; PTD014; C15orf3; PNAS-22; IRO45620
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: EID1; Polyclonal Antibody; EID1 Antibody; CRI1; EID-1; RBP21; PTD014; C15orf3; PNAS-22; IRO45620; anti-EID1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total EID1 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 0.7 mg/ml (varies by lot)
• Sequence Length: 187

• Applicable Applications for anti-EID1 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:25-1:100
• Immunogen Type: Recombinant Protein
• Immunogen Description: Fusion protein corresponding to residues near the N terminal of human EP300 interacting inhibitor of differentiation 1
• Target Name: EID1
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/20.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using at dilution 1/20.)

Related Product Information for anti-EID1 antibody

E1A-like inhibitor of differentiation-1 (EID-1), an acetyltransferase enzyme, binds both the retinoblastoma protein (Rb), a regulator of cell cycle and tissue specific transcription, and the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EID-1 inhibits cellular differentiation by blocking the histone acetyltransferase activity of p300. EID-1 also acetylates both histones and non-histone proteins such as NCOA3 co-activator. By acetylating histones, EID-1 gives a specific tag for transcriptional activation. In addition to binding Rb and p300, EID-1 also binds to phosphorylated CREB protein, mediating cAMP gene regulation. EID-1 augments the activity of phosphorylated CREB and activates transcription of cAMP responsive genes as a co-activator.

Product Categories/Family for anti-EID1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 7656938
• NCBI GeneID: 23741
• NCBI Accession #: NP_055150.1
• NCBI GenBank Nucleotide #: NM_014335.2
• UniProt Accession #: Q9Y6B2; Q8N7I4; Q9BZT9; B2RD11
• Molecular Weight: 18,616 Da
• NCBI Official Full Name: EP300-interacting inhibitor of differentiation 1
• NCBI Official Synonym Full Names: EP300 interacting inhibitor of differentiation 1
• NCBI Official Symbol: EID1
• NCBI Official Synonym Symbols: CRI1; EID-1; RBP21; PTD014; C15orf3; PNAS-22; IRO45620
• NCBI Protein Information: EP300-interacting inhibitor of differentiation 1
• UniProt Protein Name: EP300-interacting inhibitor of differentiation 1
• Protein Family: EID1-like F-box protein
• UniProt Gene Name: EID1
• UniProt Synonym Gene Names: EID-1
• UniProt Entry Name: EID1_HUMAN

Uniprot Description

EID1: Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 15q21.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: histone acetyltransferase binding; protein binding; histone acetyltransferase regulator activity; transcription corepressor activity

Biological Process: transcription, DNA-dependent; regulation of histone acetylation; negative regulation of transcription from RNA polymerase II promoter; cell cycle; negative regulation of transcription, DNA-dependent; cell differentiation