Western Blot (WB)
(EDA2R Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the EDA2R Antibody detected the EDA2R protein (arrow).)
Rabbit anti-Human EDA2R Polyclonal Antibody | anti-EDA2R antibody
EDA2R Antibody (C-term)
Western Blot (WB)
(EDA2R Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the EDA2R Antibody detected the EDA2R protein (arrow).)
Western Blot (WB)
(EDA2R Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the EDA2R Antibody detected the EDA2R protein (arrow).)
are encoded by the anhidrotic ectodermal dysplasia (EDA) gene.
Mutations in EDA give rise to a clinical syndrome characterized by
loss of hair, sweat glands, and teeth. The protein encoded by this
gene specifically binds to EDA-A2 isoform. This protein is a type
III transmembrane protein of the TNFR (tumor necrosis factor
receptor) superfamily, and contains 3 cysteine-rich repeats and a
single transmembrane domain but lacks an N-terminal signal peptide.
Multiple alternatively spliced transcript variants have been found
for this gene, but some variants lack sufficient support. [provided
by RefSeq].
Tanikawa, C., et al. Oncogene 28(34):3081-3092(2009)
Fujimoto, A., et al. J. Hum. Genet. 54(8):461-465(2009)
Hillmer, A.M., et al. Hum. Genet. 126(2):255-264(2009)
Richards, J.B., et al. Nat. Genet. 40(11):1282-1284(2008)
NCBI and Uniprot Product Information
NCBI Description
EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. The protein encoded by this gene specifically binds to EDA-A2 isoform. This protein is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2011]
Uniprot Description
EDA2R: Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq12
Cellular Component: integral to plasma membrane; integral to membrane
Molecular Function: protein binding; tumor necrosis factor receptor activity; receptor activity
Biological Process: epidermis development; tumor necrosis factor-mediated signaling pathway; multicellular organismal development; positive regulation of JNK cascade; activation of NF-kappaB transcription factor
Research Articles on EDA2R
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Product Notes
The EDA2R eda2r (Catalog #AAA9215299) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 267-297. The EDA2R Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's EDA2R can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the EDA2R eda2r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "EDA2R, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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