Rabbit anti-Human DUSP26 Polyclonal Antibody | anti-DUSP26 antibody

DUSP26 Antibody

Cat. Num. AAA9402083

• Gene Names: DUSP26; MKP8; NEAP; DSP-4; LDP-4; MKP-8; NATA1; SKRP3; DUSP24
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: DUSP26; Polyclonal Antibody; DUSP26 Antibody; MKP8; LDP-4; NATA1; SKRP3; DUSP24; anti-DUSP26 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total DUSP26 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 2.8 mg/ml (varies by lot)
• Sequence Length: 211

• Applicable Applications for anti-DUSP26 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:50-1:200
• Immunogen Type: Recombinant Protein
• Immunogen Description: Fusion protein corresponding to residues near the C terminal of human dual specificity phosphatase 26 (putative)
• Target Name: DUSP26
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/60.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/60.)

Related Product Information for anti-DUSP26 antibody

DUSP26, also designated LDP4, MKP8, NATA1 and SKRP3, is ubiquitously expressed in brain except in the hippocampus. DUSP26 dephosphorylates p38 thereby inhibiting p38-mediated apoptosis in anaplastic thyroid cancer cells. Downregulation of DUSP26 may also contribute to malignant phenotypes of glioma.

Product Categories/Family for anti-DUSP26 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 760998197
• NCBI GeneID: 78986
• NCBI Accession #: NP_001292044.1
• NCBI GenBank Nucleotide #: NM_001305115.1
• UniProt Accession #: Q9BV47; Q9BTW0; D3DSV8
• Molecular Weight: 9,652 Da
• NCBI Official Full Name: dual specificity protein phosphatase 26
• NCBI Official Synonym Full Names: dual specificity phosphatase 26 (putative)
• NCBI Official Symbol: DUSP26
• NCBI Official Synonym Symbols: MKP8; NEAP; DSP-4; LDP-4; MKP-8; NATA1; SKRP3; DUSP24
• NCBI Protein Information: dual specificity protein phosphatase 26
• UniProt Protein Name: Dual specificity protein phosphatase 26
• Protein Family: Dual specificity protein phosphatase
• UniProt Gene Name: DUSP26
• UniProt Synonym Gene Names: DUSP24; LDP4; MKP8; NATA1; SKRP3; DSP-4; LDP-4; MAP kinase phosphatase 8; MKP-8
• UniProt Entry Name: DUS26_HUMAN

NCBI Description

This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Uniprot Description

DUSP26: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.48; EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 8p12

Cellular Component: Golgi apparatus; mitochondrion; cytoplasm; nucleus

Molecular Function: protein binding; phosphoserine phosphatase activity; p53 binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; phosphoprotein phosphatase activity

Biological Process: positive regulation of cell adhesion; negative regulation of transcription from RNA polymerase II promoter; protein amino acid dephosphorylation