Rabbit DUSP22 / JSP 1 Polyclonal Antibody | anti-DUSP22 antibody

Rabbit Polyclonal to Human DUSP22 / JSP 1

Cat. Num. AAA247105

• Gene Names: DUSP22; VHX; JKAP; JSP1; MKPX; JSP-1; MKP-x; LMWDSP2; LMW-DSP2
• Reactivity: Gibbon, Gorilla, Human; Predicted Reactivity: Monkey, Bat, Dog, Hamster, Horse, Rabbit (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: DUSP22 / JSP 1; Polyclonal Antibody; Rabbit Polyclonal to Human DUSP22 / JSP 1; Anti-DUSP22 / JSP 1 Antibody (Internal) IHC-plus; DUSP22; JSP 1; JKAP; JNK-stimulating phosphatase 1; LMW-DSP2; Map kinase phosphatase x; MKPX; VHX; JNK-stimulatory phosphatase-1; JSP-1; JSP1; LMWDSP2; MKP-X; Human DUSP22; anti-DUSP22 antibody

• Host: Rabbit
• Reactivity: Gibbon, Gorilla, Human; Predicted Reactivity: Monkey, Bat, Dog, Hamster, Horse, Rabbit (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human DUSP22. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ATAD3B (45%), TAF2 (35%).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 184

• Applicable Applications for anti-DUSP22 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (1 - 7 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 20 amino acid peptide from internal region of human DUSP22. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Elephant (100%); Monkey, Marmoset, Horse (95%); Hamster, Dog, Bat, Rabbit (90%).
• Immunogen Type: Synthetic peptide
• Immunogen: DUSP22 / JSP 1 antibody was raised against synthetic 20 amino acid peptide from internal region of human DUSP22. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Elephant (100%); Monkey, Marmoset, Horse (95%); Hamster, Dog, Bat, Rabbit (90%); Mouse, Opossum, Platypus (85%); Rat, Bovine (80%).
• Antigen Modification: Internal
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-DUSP22 antibody IHC of human acinar epithelial cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-DUSP22 / JSP 1 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-DUSP22 antibody

MKPX, also known as JSP-1 for Jnk Stimulatory Phosphatase-1, belongs to the LMW-DSP subfamily of phosphatases. MKPX has been shown to have the capacity to activate the c-Jun N-terminal kinase (Jnk) signaling pathway. The activation of Jnk has been implicated in a number of important physiological processes, including embryonic morphogenesis, cell survival and apoptosis. At least two mRNA transcripts have been reported.

Product Categories/Family for anti-DUSP22 antibody

Family: Protein Phosphatase; Subfamily: LMW-DSP

NCBI and Uniprot Product Information

• NCBI GI #: 9910432
• NCBI GeneID: 56940
• NCBI Accession #: NP_064570.1
• NCBI GenBank Nucleotide #: NM_020185.4
• UniProt Accession #: Q9NRW4; Q59GW2; Q5VWR2; Q96AR1; B4DK56
• Molecular Weight: 23,268 Da
• NCBI Official Full Name: dual specificity protein phosphatase 22 isoform b
• NCBI Official Synonym Full Names: dual specificity phosphatase 22
• NCBI Official Symbol: DUSP22
• NCBI Official Synonym Symbols: VHX; JKAP; JSP1; MKPX; JSP-1; MKP-x; LMWDSP2; LMW-DSP2
• NCBI Protein Information: dual specificity protein phosphatase 22; MAP kinase phosphatase x; JNK-stimulating phosphatase 1; JNK-stimulatory phosphatase-1; mitogen-activated protein kinase phosphatase x; low molecular weight dual specificity phosphatase 2; homolog of mouse dual specificity phosphatase LMW-DSP2
• UniProt Protein Name: Dual specificity protein phosphatase 22
• Protein Family: Dual specificity protein phosphatase
• UniProt Gene Name: DUSP22
• UniProt Synonym Gene Names: JSP1; LMWDSP2; MKPX; JSP-1; LMW-DSP2; MAP kinase phosphatase x; MKP-x
• UniProt Entry Name: DUS22_HUMAN

Uniprot Description

DUSP22: Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N- terminal kinase (SAPK/JNK). Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Apoptosis; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 6p25.3

Cellular Component: cytoplasm; nucleus

Molecular Function: protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity

Biological Process: cell proliferation; apoptosis; multicellular organismal development; transforming growth factor beta receptor signaling pathway; positive regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter; protein amino acid dephosphorylation; regulation of cell proliferation; inactivation of MAPK activity