Rabbit DUSP12 Polyclonal Antibody | anti-DUSP12 antibody

DUSP12 Antibody

Cat. Num. AAA9630781

• Gene Names: DUSP12; YVH1; DUSP1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: DUSP12; Polyclonal Antibody; DUSP12 Antibody; Dual specificity phosphatase 12; Dual specificity protein phosphatase 12; Dual specificity tyrosine phosphatase YVH1; DUS12_HUMAN; DUSP 1; DUSP 12; DUSP1; Serine/threonine specific protein phosphatase; TDSP4; YVH 1; YVH1; YVH1 protein tyrosine phosphatase (S. cerevisiae) ortholog; YVH1 protein tyrosine phosphatase ortholog; anti-DUSP12 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: DUSP12 Antibody detects endogenous levels of DUSP12.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-DUSP12 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human DUSP12.
• Conjugation: Unconjugated
• Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
• Subunit Structure: Monomer.
• Tissue Specificity: Ubiquitous, highest expression in spleen, testis, ovary, and peripheral blood leukocytes and lower expression in liver and lung.
• Function: Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro) (By similarity). Has phosphatase activity with the synthetic substrate 6, 8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates.
• Note: Primarily nuclear. Detected in a mesh-like pattern in the cytosol.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-DUSP12 antibody

Nucleus; Cytoplasm; Cytosol; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 9973073
• NCBI GeneID: 11266
• UniProt Accession #: Q9UNI6; Q5VXA8
• Molecular Weight: 340
• NCBI Official Full Name: Dual specificity protein phosphatase 12
• NCBI Official Synonym Full Names: dual specificity phosphatase 12
• NCBI Official Symbol: DUSP12
• NCBI Official Synonym Symbols: YVH1; DUSP1
• NCBI Protein Information: dual specificity protein phosphatase 12; YVH1 protein-tyrosine phosphatase ortholog; dual specificity tyrosine phosphatase YVH1; serine/threonine specific protein phosphatase
• UniProt Protein Name: Dual specificity protein phosphatase 12
• Protein Family: Dual specificity protein phosphatase
• UniProt Gene Name: DUSP12
• UniProt Entry Name: DUS12_HUMAN

NCBI Description

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008]

Uniprot Description

DUSP12: is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008]

Protein type: Motility/polarity/chemotaxis; EC 3.1.3.16; EC 3.1.3.48; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 1q21-q22

Cellular Component: cytoplasm; nucleus

Molecular Function: zinc ion binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; kinase binding

Biological Process: protein modification process; protein amino acid dephosphorylation; positive regulation of glucokinase activity